SCHEMBL137918

SCHEMBL137918

CC(C)[C@H](N)C(=O)OC(=O)[C@@H]1CCCN1OC(=O)[C@@H]1CCCN1

nearest known ligand 0.34

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 10/20 0.34
DPP7 Q9UHL4 6/20 0.32
DPP8 Q6V1X1 5/20 0.32
FAP Q12884 4/20 0.32
DPP9 Q86TI2 4/20 0.32
PREP P48147 2/20 0.32
PITRM1 Q5JRX3 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL138094 0.90 DPP4 (0.38) DPP4DPP7DPP8FAPDPP9
SCHEMBL139232 0.87 DPP4 (0.35) DPP4DPP7DPP8FAPDPP9
SCHEMBL6894684 0.82 DPP4 (0.38) DPP4DPP7DPP8FAPDPP9
SCHEMBL28994810 0.82 NOS2 (0.38) DPP4DPP7DPP8FAPDPP9
SCHEMBL2543576 0.82 NOS2 (0.38) DPP4DPP7DPP8FAPDPP9
SCHEMBL1271957 0.78 DPP4 (0.40) DPP4DPP7DPP8FAPDPP9
SCHEMBL8941804 0.77 DPP4 (0.40) DPP4DPP7DPP8FAPDPP9
SCHEMBL30092801 0.75 RAB9A (0.41) DPP4DPP7DPP8FAPDPP9
SCHEMBL3236621 0.74 NOS2 (0.36) DPP4DPP7DPP8FAPDPP9
SCHEMBL11036662 0.74 DPP4 (0.47) DPP4DPP7DPP8FAPDPP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8673854-B2 Prophylactic agent for heart failure CALPIS CO., LTD. (JP) 2014-03-18 US disclosed
EP-2138184-B1 TRIPEPTIDES FOR USE IN PREVENTING KIDNEY GLOMERULAR DISEASE CALPIS CO LTD (JP) 2013-09-18 EP disclosed
EP-2130546-B1 TRIPEPTIDES FOR USE IN TREATING HEART WALL THICKENING CALPIS CO LTD (JP) 2013-02-27 EP disclosed
US-20120077735-A1 PROPHYLACTIC AGENT FOR RENAL FAILURE HIROTA TATSUHIKO (JP) 2012-03-29 US disclosed
US-20120058947-A1 PROPHYLACTIC AGENT FOR HEART FAILURE ASAHI GROUP FOODS, LTD. (JP) 2012-03-08 US disclosed
US-20100022748-A1 PROPHYLACTIC AGENT FOR RENAL FAILURE CALPIS CO., LTD. (JP) 2010-01-28 US disclosed
US-20100022747-A1 PROPHYLACTIC AGENT FOR HEART FAILURE CALPIS CO., LTD. (JP) 2010-01-28 US disclosed
EP-2138184-A1 PROPHYLACTIC AGENT FOR RENAL FAILURE Calpis Co., Ltd. (JP) 2009-12-30 EP disclosed
EP-2130546-A1 PROPHYLACTIC AGENT FOR HEART FAILURE Calpis Co., Ltd. (JP) 2009-12-09 EP disclosed