Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 3/20 | 0.63 |
| ▸ | POLA1 | P09884 | 8/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | FDPS | P14324 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | BCL9 | O00512 | 2/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hinokiol SCHEMBL854936 | 1.00 | KARS1 (0.63) | KARS1POLA1NR1I2OPRK1FDPS | |
| Ferruginol SCHEMBL13423521 | 0.82 | KARS1 (0.73) | KARS1POLA1NR1I2OPRK1FDPS | |
| Ferruginol SCHEMBL155580 | 0.82 | KARS1 (0.73) | KARS1POLA1NR1I2OPRK1FDPS | |
| Ferruginol SCHEMBL5315022 | 0.82 | KARS1 (0.73) | KARS1POLA1NR1I2OPRK1FDPS | |
| SCHEMBL29553306 | 0.80 | KARS1 (0.64) | KARS1POLA1NR1I2OPRK1FDPS | |
| SCHEMBL29414883 | 0.79 | KARS1 (0.56) | KARS1POLA1NR1I2OPRK1FDPS | |
| SCHEMBL29507670 | 0.79 | KARS1 (0.56) | KARS1POLA1NR1I2OPRK1FDPS | |
| 18-Hydroxyferruginol SCHEMBL18290210 | 0.78 | KARS1 (0.67) | KARS1POLA1NR1I2OPRK1FDPS | |
| 18-Hydroxyferruginol SCHEMBL32666150 | 0.78 | KARS1 (0.67) | KARS1POLA1NR1I2OPRK1FDPS | |
| Lambertic Acid SCHEMBL31674429 | 0.77 | NR1I2 (0.74) | KARS1POLA1NR1I2OPRK1BCL9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016192631-A1 | ABIETANE-TYPE DITERPENE COMPOUND HAVING LIPID-LOWERING ACTIVITY, METHOD FOR PREPARING SAME, AND USE OF SAME | 中国科学院上海药物研究所 | 2016-12-08 | — | — | WO | disclosed |