Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGER | Q15109 | 3/20 | 0.60 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.60 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18289567 | 0.78 | CHRM2 (0.49) | AGERMTNR1ACHRM2CHRM3ALDH1A1 | |
| SCHEMBL18279333 | 0.78 | CHRM2 (0.49) | AGERMTNR1ACHRM2CHRM3ALDH1A1 | |
| SCHEMBL19021586 | 0.77 | KDM4E (0.41) | AGERMTNR1AALDH1A1OPRM1MEN1 | |
| SCHEMBL13503843 | 0.75 | CHRM2 (0.65) | AGERMTNR1ACHRM2CHRM3ALDH1A1 | |
| SCHEMBL1169839 | 0.75 | AGER (1.00) | AGERMTNR1ACHRM2CHRM3ALDH1A1 | |
| SCHEMBL95632 | 0.75 | AGER (0.76) | AGERMTNR1ACHRM2CHRM3ALDH1A1 | |
| SCHEMBL17606640 | 0.75 | LMNA (0.50) | AGERMTNR1ACHRM2CHRM3HSD17B10 | |
| SCHEMBL21985921 | 0.74 | ALDH1A1 (0.39) | AGERMTNR1AALDH1A1HSD17B10LMNA | |
| SCHEMBL13503838 | 0.72 | CHRM2 (0.61) | AGERMTNR1ACHRM2CHRM3ALDH1A1 | |
| SCHEMBL16756697 | 0.72 | CHRM2 (0.51) | AGERMTNR1ACHRM2CHRM3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017067848-A1 | 6-[5-AMINO-6-(2-ETHOXYETHOXY)-IMIDAZO[4,5-B]PYRIDIN-3-YL]-NICOTINONITRILE DERIVATIVES AND THEIR USE AS IRAK INHIBITORS | GALAPAGOS NV (BE) | 2017-04-27 | — | — | WO | disclosed |
| WO-2016193812-A1 | SUBSTITUTED PYRIDINES AND METHOD OF USE | ABBVIE S.A.R.L. (LU) | 2016-12-08 | — | — | WO | disclosed |