SCHEMBL1829137

SCHEMBL1829137

O=C(Cl)CCSCC(Cl)C(=O)Cl

nearest known ligand 0.32

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.32
LMNA P02545 1/20 0.32
KMT2A Q03164 1/20 0.32
HSD17B10 Q99714 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
ALDH1A1 P00352 1/20 0.30
TP53 P04637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11209747 0.81
SCHEMBL11308729 0.81 TSHR (0.37) TSHRLMNA
SCHEMBL6996338 0.75 TDP1 (0.53) TSHRLMNAKMT2AHSD17B10TDP1
SCHEMBL29033989 0.72 TSHR (0.31) TSHRLMNAKMT2AHSD17B10TDP1
SCHEMBL11155753 0.71 TSHR (0.41) TSHRLMNAKMT2AHSD17B10TDP1
SCHEMBL10505708 0.69 TSHR (0.39) TSHRLMNAKMT2AHSD17B10TDP1
SCHEMBL9188315 0.67
SCHEMBL10571325 0.65 ALDH1A1 (0.44) TSHRALDH1A1TP53
SCHEMBL1013197 0.65 TSHR (0.56) TSHRLMNAKMT2AHSD17B10TDP1
SCHEMBL11458249 0.64 CPB2 (0.35) TDP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150210828-A1 STERICALLY HINDERED AMINES BASF SE (DE) 2015-07-30 US disclosed
US-9045430-B2 Sterically hindered amines BASF SE (DE) 2015-06-02 US disclosed
EP-2542526-B1 Sterically hindered amines BASF SE (DE) 2015-05-13 EP disclosed
US-20130041076-A1 STERICALLY HINDERED AMINES BASF SE (DE) 2013-02-14 US disclosed
EP-2542526-A1 STERICALLY HINDERED AMINES BASF SE (DE) 2013-01-09 EP disclosed
WO-2011107513-A1 STERICALLY HINDERED AMINES BASF SE (DE) 2011-09-09 WO disclosed
EP-2319832-A1 Sterically hindered amines BASF SE (DE) 2011-05-11 EP disclosed
US-5164435-A Polyphenylene ether, alkenyl aromatic resin, heat stability SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1992-11-17 US disclosed
EP-0479560-A2 Stabilized thermoplastic resin composition SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1992-04-08 EP disclosed
US-4367216-A X-RAYS, CONTRAST, OPACITY SCHERING AKTIENGESELLSCHAFT (DE) 1983-01-04 US disclosed
US-4321191-A THIO-CONTAINING POLYESTERS, POLYCARBONATES, AND COMPOUNDS; HEAT RESISTANCE; DISCOLORATION INHIBITION; MECHANICAL PROPERTIES ARGUS CHEMICAL CORP. (US) 1982-03-23 US disclosed
US-4233414-A FOR SYNTHETIC RESINS HEAT RESISTANCE ARGUS CHEMICAL CORPORATION (US) 1980-11-11 US disclosed
US-4174297-A Polyhydric phenol coester stabilizers ARGUS CHEMICAL CORPORATION (US) 1979-11-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150210828-A1 STERICALLY HINDERED AMINES CCNA1, C5, H1-0 TSHR 2304/4885LMNA 592/4885KMT2A 408/4885
US-20130041076-A1 STERICALLY HINDERED AMINES CCNA1, C5, H1-0 TSHR 2304/4885LMNA 592/4885KMT2A 408/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.