Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18282757 | 0.74 | DYRK1A (0.33) | DYRK1A | |
| SCHEMBL22423043 | 0.62 | DYRK1A (0.40) | DYRK1A | |
| SCHEMBL20156664 | 0.62 | DYRK1A (0.38) | DYRK1A | |
| SCHEMBL18290651 | 0.60 | — | — | |
| Hydrochloric Acid SCHEMBL20603213 | 0.58 | LRRK2 (0.30) | — | |
| SCHEMBL19011285 | 0.56 | NUDT1 (0.33) | — | |
| SCHEMBL14621843 | 0.55 | TLR8 (0.34) | — | |
| SCHEMBL14391336 | 0.55 | — | — | |
| SCHEMBL10265707 | 0.55 | CALM1 (0.40) | — | |
| SCHEMBL15214380 | 0.55 | ALDH1A1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016196071-A1 | 6-ALKYL DIHYDROPYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-12-08 | — | — | WO | disclosed |
| WO-2016191935-A1 | 6-ALKYL DIHYDROPYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-12-08 | — | — | WO | disclosed |