SCHEMBL1829446

SCHEMBL1829446

CCOP(=O)(OCC)OC1=C(C)C(C)(c2ccc(Cl)c(Cl)c2)CC(C)C1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR2 P41597 8/20 0.42
SLC6A4 P31645 6/20 0.38
SLC6A3 Q01959 6/20 0.38
SLC6A2 P23975 5/20 0.38
OPRM1 P35372 1/20 0.34
CHRNA1 P02708 1/20 0.32
CHRNG P07510 1/20 0.32
CHRNB1 P11230 1/20 0.32
CHRNB2 P17787 1/20 0.32
CHRNB4 P30926 1/20 0.32
CHRNA3 P32297 1/20 0.32
CHRNA4 P43681 1/20 0.32
CHRND Q07001 1/20 0.32
CHRM2 P08172 1/20 0.32
CHRM4 P08173 1/20 0.32
CHRM5 P08912 1/20 0.32
CYP2D6 P10635 1/20 0.32
CHRM1 P11229 1/20 0.32
CHRM3 P20309 1/20 0.32
HTR2A P28223 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3223363 0.86 CCR2 (0.49) CCR2SLC6A4SLC6A3SLC6A2OPRM1
SCHEMBL1779891 0.84 CCR2 (0.43) CCR2SLC6A4SLC6A3SLC6A2OPRM1
SCHEMBL3222866 0.77 CCR2 (0.36) CCR2SLC6A4SLC6A3SLC6A2CHRNA1
SCHEMBL1779892 0.71 CCR2 (0.44) CCR2SLC6A4SLC6A3SLC6A2OPRM1
SCHEMBL1782801 0.65 CCR2 (0.62) CCR2SLC6A4SLC6A3SLC6A2CHRNA1
SCHEMBL28393036 0.64 OPRM1 (0.43) SLC6A4SLC6A3SLC6A2OPRM1CHRM2
SCHEMBL17355866 0.60 KMT2A (0.58)
SCHEMBL1826285 0.60 CCR2 (1.00) CCR2
Bicarbonate SCHEMBL14238261 0.60 CCR2 (0.51) CCR2SLC6A4SLC6A3SLC6A2CHRNA1
SCHEMBL14237216 0.60 CCR2 (1.00) CCR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2318352-A2 CYCLOHEXENYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Bristol-Myers Squibb Company (US) 2011-05-11 EP disclosed