Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK1D | Q8IU85 | 14/20 | 0.43 |
| ▸ | BTK | Q06187 | 3/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | PIM1 | P11309 | 2/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RIPK4 | P57078 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.41 |
| ▸ | CAMK1 | Q14012 | 1/20 | 0.41 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.41 |
| ▸ | PNCK | Q6P2M8 | 1/20 | 0.41 |
| ▸ | CAMK1G | Q96NX5 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18296292 | 0.77 | BTK (0.55) | CAMK1DBTKJAK3PIM1PIM3 | |
| SCHEMBL18296078 | 0.76 | BTK (0.67) | CAMK1DBTKJAK3EGFRLCK | |
| SCHEMBL18296227 | 0.76 | BTK (0.39) | CAMK1DBTKJAK3PIM1PIM3 | |
| SCHEMBL16764183 | 0.74 | BTK (0.71) | CAMK1DBTKJAK3EGFRLCK | |
| SCHEMBL16764181 | 0.74 | BTK (0.71) | CAMK1DBTKJAK3EGFRLCK | |
| SCHEMBL2712015 | 0.74 | LRRK2 (0.48) | JAK3 | |
| SCHEMBL18779659 | 0.72 | MAP4K4 (0.46) | PIM1PIM3PIM2 | |
| SCHEMBL4827535 | 0.71 | CHRNB2 (0.54) | PIM1PIM3PIM2CHEK1 | |
| SCHEMBL30022986 | 0.71 | CAMK1D (0.53) | CAMK1DPIM1PIP5K1CCYP2C9CYP2C19 | |
| SCHEMBL4829280 | 0.71 | CHRNB2 (0.54) | PIM1PIM3PIM2CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016196776-A2 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC. (US) | 2016-12-08 | — | — | WO | disclosed |