Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.35 |
| ▸ | ELANE | P08246 | 2/20 | 0.33 |
| ▸ | CTSG | P08311 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | ESR1 | P03372 | 2/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.30 |
| ▸ | HPGD | P15428 | 2/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.30 |
| ▸ | RECQL | P46063 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.30 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2951870 | 0.80 | GABRA1 (0.55) | TP53GABRA1GABRB2ELANECTSG | |
| SCHEMBL1829639 | 0.80 | TP53 (0.37) | TP53TSHRGABRA1GABRB2ELANE | |
| SCHEMBL31132213 | 0.78 | PTPN1 (0.55) | TP53TSHRALOX15ALOX12 | |
| SCHEMBL5317566 | 0.77 | PRKCI (0.36) | GABRA1GABRB2ELANECTSGALOX15 | |
| SCHEMBL1829987 | 0.76 | TP53 (0.37) | TP53TSHRGABRA1GABRB2ELANE | |
| SCHEMBL1829471 | 0.73 | ERN1 (0.34) | TSHRALOX12MEN1KMT2AHSD17B10 | |
| SCHEMBL1830214 | 0.72 | TYR (0.50) | TP53TSHRALOX15MEN1CYP3A4 | |
| SCHEMBL5862945 | 0.72 | AHR (0.40) | ELANEALDH1A1CYP3A4MAPK1CYP1A2 | |
| SCHEMBL3272345 | 0.72 | TSHR (0.45) | TP53TSHRGABRA1GABRB2ELANE | |
| SCHEMBL9156986 | 0.71 | GABRA1 (0.48) | TP53TSHRGABRA1GABRB2ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318375-A1 | IMIDAZOLE CARBOXAMIDES | ELI LILLY AND COMPANY (US) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010009062-A1 | IMIDAZOLE CARBOXAMIDES | ELI LILLY AND COMPANY (US) | 2010-01-21 | — | — | WO | disclosed |