Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.55 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.55 |
| ▸ | ELANE | P08246 | 2/20 | 0.43 |
| ▸ | CTSG | P08311 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6346017 | 0.81 | GABRA1 (0.61) | GABRA1GABRB2ELANECTSGKDM4E | |
| SCHEMBL5319104 | 0.81 | TYR (0.40) | GABRA1GABRB2PTPN1 | |
| SCHEMBL1829702 | 0.80 | TP53 (0.37) | GABRA1GABRB2ELANECTSGKDM4E | |
| SCHEMBL5317566 | 0.80 | PRKCI (0.36) | GABRA1GABRB2ELANECTSGKDM4E | |
| SCHEMBL5587185 | 0.80 | GABRA1 (0.73) | GABRA1GABRB2ELANECTSGKDM4E | |
| SCHEMBL31015759 | 0.73 | GABRA1 (0.52) | GABRA1GABRB2ELANECTSGKDM4E | |
| SCHEMBL23387408 | 0.72 | GABRA1 (0.61) | GABRA1GABRB2ELANECTSGKDM4E | |
| SCHEMBL29079425 | 0.72 | GABRA1 (0.61) | GABRA1GABRB2ELANECTSGKDM4E | |
| SCHEMBL2096847 | 0.72 | GABRA1 (0.63) | GABRA1GABRB2KDM4EHPGDALOX15 | |
| SCHEMBL864085 | 0.72 | GABRA1 (1.00) | GABRA1GABRB2ELANECTSGKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7754742-B2 | Imidazole carboxamides | ELI LILLY AND COMPANY (US) | 2010-07-13 | — | — | US | disclosed |
| US-20100016373-A1 | IMIDAZOLE CARBOXAMIDES | ELI LILLY AND COMPANY | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016373-A1 | IMIDAZOLE CARBOXAMIDES | CYP3A4, CYP2C9, AADAC | GABRA1 839/4885GABRB2 861/4885ELANE 2701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.