Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 5/20 | 0.40 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.39 |
| ▸ | SLCO1B1 | Q9Y6L6 | 2/20 | 0.38 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.38 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.38 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.38 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1788 | 0.79 | LPAR1 (0.58) | LPAR1LPAR3SLCO1B1ABCC3ABCC4 | |
| SCHEMBL1829 | 0.79 | LPAR1 (0.58) | LPAR1LPAR3SLCO1B1ABCC3ABCC4 | |
| SCHEMBL1690 | 0.77 | LPAR1 (0.40) | LPAR1LPAR3SLCO1B1ABCC3ABCC4 | |
| SCHEMBL1691 | 0.77 | LPAR1 (0.40) | LPAR1LPAR3SLCO1B1ABCC3ABCC4 | |
| SCHEMBL2502 | 0.77 | LPAR1 (0.50) | LPAR1LPAR3SLCO1B1ABCC3ABCC4 | |
| SCHEMBL1582 | 0.77 | LPAR1 (0.50) | LPAR1LPAR3SLCO1B1ABCC3ABCC4 | |
| SCHEMBL6863 | 0.77 | SLC6A9 (0.43) | SLC6A9LPAR1LPAR3SLCO1B1HTT | |
| SCHEMBL28398519 | 0.71 | LPAR1 (0.49) | LPAR1LPAR3SLCO1B1ABCC3ABCC4 | |
| SCHEMBL1663 | 0.70 | LPAR1 (0.56) | LPAR1LPAR3SLCO1B1ABCC3ABCC4 | |
| SCHEMBL1680146 | 0.70 | BRD4 (0.38) | SLC6A9LPAR1LPAR3SLCO1B1ABCC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483253-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | claimed |
| WO-2011041729-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | claimed |