Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.38 |
| ▸ | F11 | P03951 | 2/20 | 0.38 |
| ▸ | ELANE | P08246 | 2/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.37 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.37 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.36 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.36 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.36 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.36 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1680149 | 0.80 | ELANE (0.39) | BRD4CREBBPF11ELANELPAR1 | |
| SCHEMBL4498 | 0.80 | LPAR1 (0.54) | LPAR1LPAR3ABCC3ABCC4ABCB11 | |
| SCHEMBL4561 | 0.77 | ABCC3 (0.46) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL1680150 | 0.72 | MAPT (0.37) | LPAR1LPAR3KMT2AMEN1MAPT | |
| SCHEMBL2999 | 0.71 | LPAR1 (0.46) | BRD4LPAR1LPAR3ABCC3ABCC4 | |
| SCHEMBL1830 | 0.70 | SLC6A9 (0.40) | ELANELPAR1LPAR3ABCC3ABCC4 | |
| SCHEMBL5316205 | 0.69 | ELANE (0.70) | ELANEKMT2AMEN1TDP1MAPT | |
| SCHEMBL6863 | 0.69 | SLC6A9 (0.43) | ELANELPAR1LPAR3SLCO1B1SLC6A9 | |
| SCHEMBL28398519 | 0.69 | LPAR1 (0.49) | ELANELPAR1LPAR3ABCC3ABCC4 | |
| SCHEMBL3859 | 0.69 | LPAR1 (0.51) | BRD4LPAR1LPAR3ABCC3ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483269-A2 | POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | claimed |
| WO-2011041461-A2 | POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | claimed |