Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 2/20 | 0.40 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.38 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.38 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173 | 0.77 | LPAR1 (0.51) | SLC6A9SLCO1B1L3MBTL1LPAR1LPAR2 | |
| SCHEMBL1830 | 0.77 | SLC6A9 (0.40) | SLC6A9ELANESLCO1B1L3MBTL1LPAR1 | |
| SCHEMBL6451 | 0.75 | OPRM1 (0.43) | SLCO1B1LPAR1LMNATDP1 | |
| SCHEMBL18597843 | 0.71 | MMP12 (0.41) | L3MBTL1LPAR1LPAR2LPAR3HTT | |
| SCHEMBL7260 | 0.71 | PTGER1 (0.50) | LPAR1LPAR2LPAR3 | |
| SCHEMBL7024 | 0.71 | LPAR1 (0.48) | L3MBTL1LPAR1LPAR2LPAR3HTT | |
| SCHEMBL7569 | 0.70 | AR (0.36) | SLC6A9L3MBTL1LPAR1LPAR2LPAR3 | |
| SCHEMBL6948 | 0.70 | AR (0.36) | SLC6A9L3MBTL1LPAR1LPAR2LPAR3 | |
| SCHEMBL6949 | 0.70 | AR (0.36) | SLC6A9L3MBTL1LPAR1LPAR2LPAR3 | |
| SCHEMBL18597994 | 0.70 | LPAR1 (0.48) | LPAR1LPAR2LPAR3HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |