Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | UBE2N | P61088 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MITF | O75030 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18309628 | 0.88 | ALDH1A1 (0.61) | KMT2AALDH1A1MEN1KDM4ELMNA | |
| SCHEMBL18300329 | 0.87 | KMT2A (0.64) | KMT2AALDH1A1MEN1KDM4ELMNA | |
| SCHEMBL18309632 | 0.87 | ALDH1A1 (0.55) | KMT2AALDH1A1MEN1KDM4ELMNA | |
| SCHEMBL18300589 | 0.86 | ALDH1A1 (0.61) | KMT2AALDH1A1MEN1KDM4ELMNA | |
| SCHEMBL18300584 | 0.84 | ALDH1A1 (0.68) | KMT2AALDH1A1MEN1KDM4ELMNA | |
| SCHEMBL18309614 | 0.83 | ALDH1A1 (0.67) | KMT2AALDH1A1MEN1KDM4ELMNA | |
| SCHEMBL18309602 | 0.83 | KMT2A (0.52) | KMT2AALDH1A1MEN1KDM4ELMNA | |
| SCHEMBL18300099 | 0.82 | KMT2A (0.61) | KMT2AALDH1A1MEN1KDM4ELMNA | |
| SCHEMBL18300415 | 0.82 | KMT2A (0.61) | KMT2AALDH1A1MEN1KDM4ELMNA | |
| SCHEMBL18309615 | 0.82 | ALDH1A1 (0.68) | KMT2AALDH1A1MEN1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9988395-B2 | Antiparasitic compositions and methods utilizing substituted 5,5,7,7-tetramethyl-4,5,6,7-tetrahydrothieno[2,3-C]pyridine derivatives | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2018-06-05 | — | — | US | disclosed |
| US-20170349606-A1 | ANTIPARASITIC COMPOSITIONS AND METHODS UTILIZING SUBSTITUTED 5,5,7,7-TETRAMETHYL-4,5,6,7-TETRAHYDROTHIENO[2,3-C] PYRIDINE DERIVATIVES | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-12-07 | — | — | US | disclosed |
| US-20160362420-A1 | Antiparasitic Compositions and Methods Utilizing Substituted 5,5,7,7-Tetramethyl- 4,5,6,7-Tetrahydrothieno[2,3-C]Pyridine Derivatives | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2016-12-15 | — | — | US | disclosed |
| US-20160362420-A1 | Antiparasitic Compositions and Methods Utilizing Substituted 5,5,7,7-Tetramethyl- 4,5,6,7-Tetrahydrothieno[2,3-C]Pyridine Derivatives | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2016-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170349606-A1 | ANTIPARASITIC COMPOSITIONS AND METHODS UTILIZING SUBSTITUTED 5,5,7,7-TETRAMETHYL-4,5,6,7-TETRAHYDROTHIENO[2,3-C] PYRIDINE DERIVATIVES | COX5B, COX6C, CYCS | KMT2A 3427/4885ALDH1A1 2095/4885MEN1 3083/4885 |
| US-20160362420-A1 | Antiparasitic Compositions and Methods Utilizing Substituted 5,5,7,7-Tetramethyl- 4,5,6,7-Tetrahydrothieno[2,3-C]Pyridine Derivatives | COX5B, COX6C, CYCS | KMT2A 3427/4885ALDH1A1 2095/4885MEN1 3083/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.