Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | FBP1 | P09467 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7097682 | 0.88 | HSD11B1 (0.47) | HSD11B1NFE2L2PTGS1TNFRSF1ADRD2 | |
| SCHEMBL7097687 | 0.88 | HSD11B1 (0.47) | HSD11B1NFE2L2PTGS1TNFRSF1ADRD2 | |
| SCHEMBL4772823 | 0.80 | NFE2L2 (0.43) | HSD11B1NFE2L2PTGS1TNFRSF1ADRD2 | |
| SCHEMBL15050819 | 0.80 | NFE2L2 (0.47) | HSD11B1NFE2L2PTGS1TRPA1ALOX5 | |
| SCHEMBL29278715 | 0.80 | GRIK1 (0.41) | GRIK1GRIK2 | |
| SCHEMBL4772837 | 0.80 | NFE2L2 (0.43) | HSD11B1NFE2L2PTGS1TNFRSF1ADRD2 | |
| SCHEMBL5728588 | 0.80 | NFE2L2 (0.43) | HSD11B1NFE2L2PTGS1DRD2GRIK1 | |
| SCHEMBL15050816 | 0.80 | NFE2L2 (0.47) | HSD11B1NFE2L2PTGS1TRPA1ALOX5 | |
| SCHEMBL15323034 | 0.79 | HSD11B1 (0.38) | HSD11B1NFE2L2PTGS1TNFRSF1ATRPA1 | |
| SCHEMBL5470587 | 0.79 | PAM (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321287-B1 | 4,5-DIHYDRO-OXAZOL-2-YL DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2015-11-11 | — | — | EP | disclosed |
| EP-2321287-A1 | 4,5-DIHYDRO-OXAZOL-2-YL DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010010014-A1 | 4,5-DIHYDRO-OXAZOL-2-YL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-01-28 | — | — | WO | disclosed |
| EP-0068331-A1 | Tetrahydrofuran compounds and analogs thereof | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1983-01-05 | — | — | EP | disclosed |