Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1827969 | 0.86 | MAPK14 (0.37) | MAPK14RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL1829956 | 0.82 | MAPK14 (0.40) | ELANEMAPK14CYP3A4CYP2C9RAB9A | |
| SCHEMBL5230729 | 0.82 | MAPK14 (0.41) | MAPK14RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL1830664 | 0.76 | GRM2 (0.48) | MAPK14CYP2C9MAPTSMN1; SMN2L3MBTL1 | |
| Hydrochloric Acid SCHEMBL1828417 | 0.76 | GRM2 (0.41) | ELANEERN1PPARGPPARDPTPN2 | |
| SCHEMBL16096871 | 0.72 | LMNA (0.50) | MAPK14CYP2C9NPC1MAPTSMN1; SMN2 | |
| SCHEMBL1827966 | 0.72 | MAPT (0.43) | MAPK14CYP2C9MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL2892014 | 0.72 | MAPT (0.56) | MAPK14CYP2C9MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL2893555 | 0.72 | MAPK14 (0.43) | MAPK14RAB9AMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL9026243 | 0.70 | MAPT (0.45) | RAB9AMAPTSMN1; SMN2L3MBTL1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318375-A1 | IMIDAZOLE CARBOXAMIDES | ELI LILLY AND COMPANY (US) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010009062-A1 | IMIDAZOLE CARBOXAMIDES | ELI LILLY AND COMPANY (US) | 2010-01-21 | — | — | WO | disclosed |