Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CCR5 | P51681 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | LIPE | Q05469 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23046957 | 0.80 | HTR1A (0.61) | MAPTMAPK1TDP1L3MBTL1CCR5 | |
| SCHEMBL9026235 | 0.78 | PTPN1 (0.46) | MAPTMAPK1TDP1L3MBTL1HTR1A | |
| SCHEMBL3023248 | 0.77 | ALOX5 (0.50) | MAPTMAPK1TDP1L3MBTL1RAB9A | |
| SCHEMBL19692666 | 0.76 | TRPM8 (0.51) | MAPTHTR1ADRD2SMN1; SMN2 | |
| SCHEMBL13544817 | 0.76 | LMNA (0.41) | MAPTMAPK1TDP1L3MBTL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL19692661 | 0.75 | LTA4H (0.50) | MAPTHTR1ADRD2 | |
| SCHEMBL8070855 | 0.74 | PTGER1 (0.47) | ALDH1A1GLRA1PTGER1PTGER4PTGER3 | |
| SCHEMBL8078598 | 0.74 | PTGER4 (0.48) | GLRA1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL24435135 | 0.73 | ABCB1 (0.48) | MAPTMAPK1TDP1L3MBTL1ALDH1A1 | |
| SCHEMBL1829956 | 0.73 | MAPK14 (0.40) | MAPTMAPK1TDP1L3MBTL1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0411150-B1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMA CO LTD (JP) | 1996-11-27 | — | — | EP | disclosed |
| US-5238938-A | Nephrosis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-08-24 | — | — | US | disclosed |
| EP-0411150-A1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-02-06 | — | — | EP | disclosed |