Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 3/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.39 |
| ▸ | RXRA | P19793 | 2/20 | 0.39 |
| ▸ | RXRB | P28702 | 2/20 | 0.39 |
| ▸ | RXRG | P48443 | 2/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1827969 | 0.82 | MAPK14 (0.37) | MAPK14NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL1830665 | 0.82 | ELANE (0.38) | MAPK14NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL17141460 | 0.77 | HTR2C (0.51) | PTPN1PTPN6PTPN2RXRARXRB | |
| SCHEMBL5810886 | 0.77 | NPC1 (0.41) | NPC1MAPTRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL2893555 | 0.76 | MAPK14 (0.43) | MAPK14MAPTRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL3848203 | 0.76 | BCHE (0.51) | SMN1; SMN2L3MBTL1HTR1ABCHE | |
| SCHEMBL6888448 | 0.76 | BCHE (0.51) | SMN1; SMN2L3MBTL1HTR1ABCHE | |
| SCHEMBL22973045 | 0.75 | MAPT (0.52) | NPC1MAPTRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL16096871 | 0.74 | LMNA (0.50) | MAPK14NPC1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL2892014 | 0.74 | MAPT (0.56) | MAPK14MAPTSMN1; SMN2L3MBTL1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817300-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006057860-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2006-06-01 | — | — | WO | disclosed |