Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2729280 | 0.78 | TRPM8 (0.70) | TRPM8L3MBTL1POLB | |
| SCHEMBL23126358 | 0.76 | MAOB (0.55) | MAPTALDH1A1TRPM8L3MBTL1RAB9A | |
| SCHEMBL22074382 | 0.76 | TRPM8 (0.63) | MAPTALDH1A1TRPM8L3MBTL1RAB9A | |
| SCHEMBL20363079 | 0.75 | TRPM8 (0.63) | MAPTALDH1A1TRPM8RAB9ANPC1 | |
| SCHEMBL10270943 | 0.74 | TRPM8 (1.00) | MAPTALDH1A1TRPM8L3MBTL1RAB9A | |
| SCHEMBL11699284 | 0.72 | HPGD (0.55) | MAPTALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL22221556 | 0.72 | MAOB (0.64) | MAPTRAB9ANPC1MAOBSMN1; SMN2 | |
| SCHEMBL2729496 | 0.72 | FKBP1A (0.63) | MAPTALDH1A1TRPM8RAB9ANPC1 | |
| SCHEMBL10270781 | 0.72 | TRPM8 (1.00) | MAPTALDH1A1TRPM8RAB9ANPC1 | |
| SCHEMBL984460 | 0.72 | MAOB (0.68) | MAPTRAB9ANPC1MAOBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3115045-A2 | DETECTION AND USE OF LOW MOLECULAR WEIGHT MODULATORS OF THE COLD MENTHOL RECEPTOR TRPM8 | BASF SE (DE) | 2017-01-11 | — | — | EP | disclosed |
| EP-3103447-A1 | DETECTION AND USE OF LOW MOLECULAR WEIGHT MODULATORS OF THE COLD MENTHOL RECEPTOR TRPM8 | BASF SE (DE) | 2016-12-14 | — | — | EP | disclosed |