Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.43 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7317851 | 0.80 | HDAC8 (0.46) | HPGDSIGMAR1HDAC8HDAC6HDAC1 | |
| SCHEMBL7314337 | 0.80 | FFAR1 (0.54) | HPGDSIGMAR1HDAC8HDAC6HDAC1 | |
| Hydrochloric Acid SCHEMBL7317863 | 0.79 | FFAR1 (0.53) | HPGDSIGMAR1HDAC8HDAC6HDAC1 | |
| SCHEMBL3977676 | 0.79 | ALDH1A1 (0.71) | ALDH1A1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL1224015 | 0.78 | ALDH1A1 (1.00) | ALDH1A1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL1224012 | 0.78 | ALDH1A1 (1.00) | ALDH1A1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL1831403 | 0.78 | SLC6A2 (0.56) | HPGDHDAC8HDAC6HDAC1HAO1 | |
| SCHEMBL1829983 | 0.75 | ALDH1A1 (0.69) | ALDH1A1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7332673 | 0.73 | HDAC8 (0.69) | ALDH1A1CYP3A4HDAC8HDAC6HDAC1 | |
| SCHEMBL15281965 | 0.72 | ALDH1A1 (0.60) | ALDH1A1CYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130317025-A1 | PDE-10 INHIBITORS | ENVIVO PHARMACEUTICALS INC (US) | 2013-11-28 | — | — | US | disclosed |
| US-8481532-B2 | PDE-10 inhibitors | ENVIVO PHARMACEUTICALS, INC. (US) | 2013-07-09 | — | — | US | disclosed |
| US-8481532-B2 | PDE-10 inhibitors | ENVIVO PHARMACEUTICALS, INC. (US) | 2013-07-09 | — | — | US | disclosed |
| US-8481532-B2 | PDE-10 inhibitors | ENVIVO PHARMACEUTICALS, INC. (US) | 2013-07-09 | — | — | US | disclosed |
| US-20110178083-A1 | PDE-10 INHIBITORS | ENVIVO PHARMACEUTICALS, INC. | 2011-07-21 | — | — | US | disclosed |
| US-20110178083-A1 | PDE-10 INHIBITORS | ENVIVO PHARMACEUTICALS, INC. | 2011-07-21 | — | — | US | disclosed |
| US-20110178083-A1 | PDE-10 INHIBITORS | ENVIVO PHARMACEUTICALS, INC. | 2011-07-21 | — | — | US | disclosed |
| EP-2318410-A2 | NEW SMALL-MOLECULE PDE-10 INHIBITORS | Envivo Pharmaceuticals, Inc. (US) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010006130-A2 | PDE-10 INHIBITORS | ENVIVO PHARMACEUTICALS, INC. (US) | 2010-01-14 | — | — | WO | disclosed |
| WO-2010006130-A2 | PDE-10 INHIBITORS | ENVIVO PHARMACEUTICALS, INC. (US) | 2010-01-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130317025-A1 | PDE-10 INHIBITORS | PDE12, PDE10A, PDE2A | ALDH1A1 954/4885CYP1A2 327/4885CYP3A4 659/4885 |
| US-20110178083-A1 | PDE-10 INHIBITORS | PDE12, PDE10A, PDE2A | ALDH1A1 954/4885CYP1A2 327/4885CYP3A4 659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.