Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2534872 | 0.97 | KDM4E (0.42) | L3MBTL1KDM4EHTTRECQLALDH1A1 | |
| Hydrochloric Acid SCHEMBL2532416 | 0.97 | L3MBTL1 (0.43) | L3MBTL1KDM4EHTTRECQLALDH1A1 | |
| SCHEMBL11119 | 0.93 | — | — | |
| Fluoride SCHEMBL25246136 | 0.90 | KDM4E (0.42) | L3MBTL1KDM4EHTTRECQLALDH1A1 | |
| SCHEMBL7790112 | 0.90 | KDM4E (0.42) | L3MBTL1KDM4EHTTRECQLALDH1A1 | |
| Hydrogen Sulfide SCHEMBL3631297 | 0.90 | KDM4E (0.42) | L3MBTL1KDM4EHTTRECQLALDH1A1 | |
| SCHEMBL3631301 | 0.90 | KDM4E (0.42) | L3MBTL1KDM4EHTTRECQLALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL733845 | 0.90 | KDM4E (0.42) | L3MBTL1KDM4EHTTRECQLALDH1A1 | |
| Iodide SCHEMBL1835511 | 0.90 | KDM4E (0.42) | L3MBTL1KDM4EHTTRECQLALDH1A1 | |
| SCHEMBL26967079 | 0.90 | KDM4E (0.42) | L3MBTL1KDM4EHTTRECQLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2322497-A1 | Ionic liquids comprising nitrogen containing cations | Innovia Films Limited (GB) | 2011-05-18 | — | — | EP | disclosed |