Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.77 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.74 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.59 |
| ▸ | BACE1 | P56817 | 4/20 | 0.58 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.58 |
| ▸ | BRD4 | O60885 | 1/20 | 0.58 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.53 |
| ▸ | SALL4 | Q9UJQ4 | 1/20 | 0.53 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25416714 | 0.87 | ADRA1B (0.91) | TOP2AADRA1BHDAC4HDAC7HDAC9 | |
| SCHEMBL25414843 | 0.86 | ADRA1B (1.00) | TOP2AADRA1BHDAC4HDAC7HDAC9 | |
| SCHEMBL18313471 | 0.81 | MAPT (0.77) | TOP2AADRA1BBACE1BRD4ALDH1A1 | |
| SCHEMBL28600538 | 0.81 | ADRA1B (0.80) | TOP2AADRA1BHDAC4HDAC7HDAC9 | |
| SCHEMBL16424708 | 0.81 | ADRA1B (0.80) | TOP2AADRA1BHDAC4HDAC7HDAC9 | |
| SCHEMBL6643374 | 0.78 | ADRA1B (0.74) | TOP2AADRA1BHDAC4HDAC7HDAC9 | |
| SCHEMBL18313625 | 0.78 | TUBB4A (0.79) | BRD4TRIM24TRIM33ALDH1A1KDM4E | |
| SCHEMBL27101733 | 0.74 | ADRA1B (0.67) | TOP2AADRA1BHDAC4HDAC7HDAC9 | |
| SCHEMBL6646005 | 0.74 | ADRA1B (0.76) | TOP2AADRA1BHDAC4HDAC7HDAC9 | |
| SCHEMBL2992178 | 0.74 | ADRA1B (0.60) | TOP2AADRA1BHDAC4HDAC7HDAC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016201370-A1 | COMBINATION THERAPY OF TRANSCRIPTION INHIBITORS AND KINASE INHIBITORS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2016-12-15 | — | — | WO | disclosed |