Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1B | P35368 | 1/20 | 0.74 |
| ▸ | BACE1 | P56817 | 6/20 | 0.63 |
| ▸ | BACE2 | Q9Y5Z0 | 6/20 | 0.63 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.62 |
| ▸ | TUBB | P07437 | 1/20 | 0.62 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.62 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.62 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.62 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.62 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.62 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.62 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.62 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.62 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.62 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.62 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.62 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.62 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.62 |
| ▸ | TOP2A | P11388 | 1/20 | 0.62 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6649635 | 0.85 | GAA (0.60) | ADRA1BBACE1BACE2TUBB4ATUBB | |
| SCHEMBL25414843 | 0.85 | ADRA1B (1.00) | ADRA1BBACE1BACE2TOP2ATRIM24 | |
| SCHEMBL25416714 | 0.84 | ADRA1B (0.91) | ADRA1BBACE1BACE2TUBB4ATUBB | |
| SCHEMBL6646005 | 0.79 | ADRA1B (0.76) | ADRA1BBACE1BACE2TOP2ATRIM24 | |
| SCHEMBL7011739 | 0.78 | GAA (0.52) | ADRA1BBACE1BACE2TUBB4ATUBB | |
| SCHEMBL4719562 | 0.78 | IDO1 (0.73) | ADRA1BTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL18313530 | 0.78 | TOP2A (0.77) | ADRA1BBACE1BACE2TOP2ATRIM24 | |
| SCHEMBL16424708 | 0.78 | ADRA1B (0.80) | ADRA1BBACE1BACE2TUBB4ATUBB | |
| SCHEMBL28600538 | 0.78 | ADRA1B (0.80) | ADRA1BBACE1BACE2TUBB4ATUBB | |
| SCHEMBL20889444 | 0.77 | ADRA1B (0.65) | ADRA1BBACE1BACE2TOP2ATRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218382-B1 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2004-01-28 | — | — | EP | claimed |
| US-6638933-B2 | Analgesics | GRUENENTHAL GMBH (DE) | 2003-10-28 | — | — | US | claimed |
| JP-2003511451-A | — | — | 2003-03-25 | — | — | JP | claimed |
| US-20030018032-A1 | Bicyclic imidazo-3-yl-amine derivatives | GRUENENTHAL GMBH | 2003-01-23 | — | — | US | claimed |
| EP-1218382-A2 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES | Grünenthal GmbH (DE) | 2002-07-03 | — | — | EP | claimed |
| WO-2001027111-A2 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES | Grünenthal GmbH (DE) | 2001-04-19 | — | — | WO | claimed |
| CN-1257169-C | Bicyclic imidazol-3-yl-amine derivatives | GRUELENTHAL GMBH (DE) | 2006-05-24 | — | — | CN | disclosed |
| EP-1218382-B1 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2004-01-28 | — | — | EP | disclosed |
| US-6638933-B2 | Analgesics | GRUENENTHAL GMBH (DE) | 2003-10-28 | — | — | US | disclosed |
| US-20030018032-A1 | Bicyclic imidazo-3-yl-amine derivatives | GRUENENTHAL GMBH | 2003-01-23 | — | — | US | disclosed |
| EP-1218382-A2 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES | Grünenthal GmbH (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001027111-A2 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES | Grünenthal GmbH (DE) | 2001-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030018032-A1 | Bicyclic imidazo-3-yl-amine derivatives | OPRK1, IPO4, GRIN3A | ADRA1B 477/4885BACE1 4157/4885BACE2 3778/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.