Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 7/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 11/20 | 0.35 |
| ▸ | TGFBR2 | P37173 | 4/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1830028 | 0.83 | MET (0.54) | METPIK3CA | |
| SCHEMBL1830965 | 0.81 | MET (0.51) | METPIK3CA | |
| SCHEMBL2531646 | 0.80 | MET (0.59) | METPIK3CA | |
| SCHEMBL2530711 | 0.78 | MET (0.61) | METPIK3CA | |
| SCHEMBL2531816 | 0.78 | MET (0.38) | METPIK3CATGFBR1FLT3 | |
| SCHEMBL1840243 | 0.76 | MET (0.50) | METPIK3CA | |
| SCHEMBL1831478 | 0.71 | TGFBR1 (0.41) | PIK3CATGFBR1TGFBR2FLT3 | |
| SCHEMBL1841045 | 0.71 | MET (0.66) | MET | |
| SCHEMBL2529642 | 0.71 | MET (0.54) | METPIK3CA | |
| SCHEMBL2536920 | 0.69 | ABL1 (0.52) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318382-A1 | NOVEL IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF, USE THEREOF AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE IN PARTICULAR AS MET INHIBITORS | Sanofi-Aventis (FR) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010007317-A1 | NOVEL IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF, USE THEREOF AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE IN PARTICULAR AS MET INHIBITORS | SANOFI-AVENTIS (FR) | 2010-01-21 | — | — | WO | disclosed |