Sugi Predict

Sugi Predict / Compounds / SCHEMBL18318448

SCHEMBL18318448

SCHEMBL18318448

CCNC(=O)N1CCC(Oc2ccc(-c3ccc4c(C)nccc4c3)cc2)CC1

nearest known ligand 0.52

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ JUN P05412 4/20 0.44
▸ MAPK8 P45983 4/20 0.44
▸ MAPK9 P45984 4/20 0.44
▸ CDK2 P24941 2/20 0.44
▸ CHRNA7 P36544 1/20 0.44
▸ EPHX2 P34913 9/20 0.43
▸ CYP2C9 P11712 3/20 0.42
▸ CYP2J2 P51589 3/20 0.42
▸ MAPK10 P53779 1/20 0.42
▸ PRMT3 O60678 1/20 0.41
▸ MMP1 P03956 1/20 0.41
▸ FDPS P14324 1/20 0.40
▸ ACACB O00763 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18318337 0.93 CHRNA7 (0.43) CHRNA7EPHX2CYP2C9CYP2J2PRMT3
SCHEMBL18318040 0.91 CHRNA7 (0.43) CHRNA7EPHX2CYP2C9CYP2J2PRMT3
SCHEMBL18318354 0.91 FDPS (0.42) CHRNA7EPHX2CYP2C9CYP2J2PRMT3
SCHEMBL18318731 0.90 CHRNA7 (0.42) CHRNA7EPHX2CYP2C9CYP2J2PRMT3
SCHEMBL18318839 0.89 EPHX2 (0.45) CHRNA7EPHX2PRMT3MMP1FDPS
SCHEMBL18318252 0.88 NAMPT (0.41) CHRNA7EPHX2PRMT3MMP1FDPS
SCHEMBL18318344 0.87 PIK3CD (0.45) PRMT3
SCHEMBL18319103 0.85 CHEK2 (0.43) PRMT3FDPS
SCHEMBL18318388 0.85 FDPS (0.41) CHRNA7EPHX2FDPSACACB
SCHEMBL18319501 0.84 LMNA (0.48) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11702388-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2023-07-18 — — US claimed
US-20210230116-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2021-07-29 — — US claimed
CN-107847765-B 1, 4-substituted piperidine derivatives 89生物有限公司 2021-05-04 — — CN claimed
US-10851057-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2020-12-01 — — US claimed
EP-3310441-B1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES 89BIO LTD (IL) 2020-07-29 — — EP claimed
US-20190152913-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2019-05-23 — — US claimed
US-10221135-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2019-03-05 — — US claimed
US-20180179159-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2018-06-28 — — US claimed
EP-3310441-A1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES Cephalon, Inc. (US) 2018-04-25 — — EP claimed
US-9902696-B2 1,4-substituted piperidine derivatives CEPHALON, INC. (US) 2018-02-27 — — US claimed
WO-2016205633-A1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON, INC. (US) 2016-12-22 — — WO claimed
US-20160368874-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2016-12-22 — — US claimed
US-20250257035-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2025-08-14 — — US disclosed
US-12098130-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2024-09-24 — — US disclosed
US-20230391723-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2023-12-07 — — US disclosed
US-11702388-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2023-07-18 — — US disclosed
US-9902696-B2 1,4-substituted piperidine derivatives CEPHALON, INC. (US) 2018-02-27 — — US disclosed
US-20160368874-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2016-12-22 — — US disclosed
WO-2016205633-A1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON, INC. (US) 2016-12-22 — — WO disclosed
WO-2016205633-A1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON, INC. (US) 2016-12-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250257035-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A JUN 3803/4885MAPK8 3802/4885MAPK9 3187/4885
US-20190152913-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES FASN, CES1, CPT1A JUN 3803/4885MAPK8 3802/4885MAPK9 3187/4885
US-20230391723-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A JUN 3803/4885MAPK8 3802/4885MAPK9 3187/4885
US-20160368874-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES FASN, CES1, CPT1A JUN 3803/4885MAPK8 3802/4885MAPK9 3187/4885
US-20210230116-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A JUN 3803/4885MAPK8 3802/4885MAPK9 3187/4885
US-10221135-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A JUN 3803/4885MAPK8 3802/4885MAPK9 3187/4885
US-11702388-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A JUN 3803/4885MAPK8 3802/4885MAPK9 3187/4885
US-12098130-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A JUN 3803/4885MAPK8 3802/4885MAPK9 3187/4885
US-10851057-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A JUN 3803/4885MAPK8 3802/4885MAPK9 3187/4885
US-20180179159-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES FASN, CES1, CPT1A JUN 3726/4885MAPK8 3785/4885MAPK9 3240/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.