Sugi Predict

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SCHEMBL18318337

SCHEMBL18318337

CCCNC(=O)N1CCC(Oc2ccc(-c3ccc4c(C)nccc4c3)cc2)CC1

nearest known ligand 0.44

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ CHRNA7 P36544 1/20 0.43
▸ EPHX2 P34913 9/20 0.41
▸ CYP2C9 P11712 4/20 0.41
▸ CYP2J2 P51589 3/20 0.41
▸ PRMT3 O60678 1/20 0.40
▸ MMP1 P03956 1/20 0.40
▸ NAMPT P43490 1/20 0.40
▸ FDPS P14324 1/20 0.39
▸ CYP2C19 P33261 2/20 0.38
▸ ACACB O00763 1/20 0.38
▸ MEN1 O00255 1/20 0.38
▸ KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18318448 0.93 JUN (0.44) CHRNA7EPHX2CYP2C9CYP2J2PRMT3
SCHEMBL18318040 0.89 CHRNA7 (0.43) CHRNA7EPHX2CYP2C9CYP2J2PRMT3
SCHEMBL18318354 0.89 FDPS (0.42) CHRNA7EPHX2CYP2C9CYP2J2PRMT3
SCHEMBL18318731 0.88 CHRNA7 (0.42) CHRNA7EPHX2CYP2C9CYP2J2PRMT3
SCHEMBL18318252 0.88 NAMPT (0.41) CHRNA7EPHX2PRMT3MMP1NAMPT
SCHEMBL18318839 0.88 EPHX2 (0.45) CHRNA7EPHX2PRMT3MMP1FDPS
SCHEMBL18318344 0.86 PIK3CD (0.45) PRMT3NAMPTKMT2A
SCHEMBL18319103 0.84 CHEK2 (0.43) PRMT3FDPS
SCHEMBL18318388 0.84 FDPS (0.41) CHRNA7EPHX2FDPSACACB
SCHEMBL18319501 0.83 LMNA (0.48) NAMPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11702388-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2023-07-18 — — US claimed
US-20210230116-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2021-07-29 — — US claimed
CN-107847765-B 1, 4-substituted piperidine derivatives 89生物有限公司 2021-05-04 — — CN claimed
US-10851057-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2020-12-01 — — US claimed
EP-3310441-B1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES 89BIO LTD (IL) 2020-07-29 — — EP claimed
US-20190152913-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2019-05-23 — — US claimed
US-10221135-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2019-03-05 — — US claimed
US-20180179159-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2018-06-28 — — US claimed
EP-3310441-A1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES Cephalon, Inc. (US) 2018-04-25 — — EP claimed
US-9902696-B2 1,4-substituted piperidine derivatives CEPHALON, INC. (US) 2018-02-27 — — US claimed
US-20160368874-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2016-12-22 — — US claimed
WO-2016205633-A1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON, INC. (US) 2016-12-22 — — WO claimed
US-20250257035-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2025-08-14 — — US disclosed
US-12098130-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2024-09-24 — — US disclosed
US-20230391723-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2023-12-07 — — US disclosed
US-11702388-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2023-07-18 — — US disclosed
US-9902696-B2 1,4-substituted piperidine derivatives CEPHALON, INC. (US) 2018-02-27 — — US disclosed
WO-2016205633-A1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON, INC. (US) 2016-12-22 — — WO disclosed
US-20160368874-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2016-12-22 — — US disclosed
WO-2016205633-A1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON, INC. (US) 2016-12-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250257035-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A CHRNA7 4048/4885EPHX2 1352/4885CYP2C9 252/4885
US-20190152913-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES FASN, CES1, CPT1A CHRNA7 4048/4885EPHX2 1352/4885CYP2C9 252/4885
US-20230391723-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A CHRNA7 4048/4885EPHX2 1352/4885CYP2C9 252/4885
US-20160368874-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES FASN, CES1, CPT1A CHRNA7 4048/4885EPHX2 1352/4885CYP2C9 252/4885
US-20210230116-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A CHRNA7 4048/4885EPHX2 1352/4885CYP2C9 252/4885
US-10221135-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A CHRNA7 4048/4885EPHX2 1352/4885CYP2C9 252/4885
US-11702388-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A CHRNA7 4048/4885EPHX2 1352/4885CYP2C9 252/4885
US-12098130-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A CHRNA7 4048/4885EPHX2 1352/4885CYP2C9 252/4885
US-10851057-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A CHRNA7 4048/4885EPHX2 1352/4885CYP2C9 252/4885
US-20180179159-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES FASN, CES1, CPT1A CHRNA7 4113/4885EPHX2 1374/4885CYP2C9 259/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.