Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29768359 | 0.81 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DTAAR1 | |
| SCHEMBL15053663 | 0.81 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DTAAR1 | |
| SCHEMBL30422333 | 0.80 | TAAR1 (0.61) | PDE4APDE4BPDE4CPDE4DTAAR1 | |
| SCHEMBL12486805 | 0.80 | TAAR1 (0.61) | PDE4APDE4BPDE4CPDE4DTAAR1 | |
| SCHEMBL13683163 | 0.79 | THRB (0.46) | THRBRORCPDE4APDE4BPDE4C | |
| SCHEMBL13241837 | 0.79 | PDE4A (0.43) | THRBRORCPDE4APDE4BPDE4C | |
| SCHEMBL14985952 | 0.77 | TAAR1 (0.50) | THRBRORCTAAR1LPAR1P2RX3 | |
| SCHEMBL13696483 | 0.77 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DTAAR1 | |
| SCHEMBL23288682 | 0.76 | THRB (0.37) | THRBRORCLPAR1P2RX3P2RX2 | |
| SCHEMBL19628279 | 0.76 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107743488-B | 2-oxo-1, 3, 8-triazaspiro [4.5] decan-3-yl ] carboxylic acid derivatives | 伊莱利利公司 | 2020-09-11 | — | — | CN | disclosed |
| EP-3310780-A1 | 2-OXO-1,3,8-TRIAZASPIRO[4.5]DECAN-3-YL]CARBOXYLIC ACID DERIVATIVES | Eli Lilly and Company (US) | 2018-04-25 | — | — | EP | disclosed |
| US-9920056-B2 | 2-oxo-1,3,8-triazaspiro[4.5]decan-3-yl] carboxylic acid derivatives | ELI LILLY AND COMPANY (US) | 2018-03-20 | — | — | US | disclosed |
| US-20160368922-A1 | 2-OXO-1,3,8-TRIAZASPIRO[4.5]DECAN-3-YL] CARBOXYLIC ACID DERIVATIVES | ELI LILLY AND COMPANY | 2016-12-22 | — | — | US | disclosed |
| WO-2016205032-A1 | 2-OXO-1,3,8-TRIAZASPIRO[4.5]DECAN-3-YL] CARBOXYLIC ACID DERIVATIVES | ELI LILLY AND COMPANY (US) | 2016-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160368922-A1 | 2-OXO-1,3,8-TRIAZASPIRO[4.5]DECAN-3-YL] CARBOXYLIC ACID DERIVATIVES | SLC5A2, SLC5A1, GPR119 | THRB 530/4885RORC 1231/4885PDE4A 1173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.