Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19650317 | 0.84 | GAA (0.44) | THRBRORCP2RX3P2RX2GAA | |
| SCHEMBL10102822 | 0.79 | P2RX3 (0.36) | P2RX3P2RX2GAAPOLBGFER | |
| SCHEMBL18319261 | 0.76 | THRB (0.46) | THRBRORCP2RX3P2RX2GAA | |
| SCHEMBL12534319 | 0.74 | POLB (0.46) | THRBRORCP2RX3P2RX2GAA | |
| SCHEMBL23244835 | 0.74 | THRB (0.38) | THRBRORCP2RX3P2RX2GAA | |
| SCHEMBL738874 | 0.74 | GAA (0.48) | THRBRORCP2RX3P2RX2GAA | |
| SCHEMBL14039591 | 0.74 | NPC1 (0.52) | THRBRORCP2RX3P2RX2GAA | |
| SCHEMBL16117969 | 0.73 | GAA (0.57) | THRBP2RX3P2RX2GAAPOLB | |
| SCHEMBL23268676 | 0.73 | P2RX3 (0.44) | THRBRORCP2RX3P2RX2GAA | |
| SCHEMBL16160619 | 0.73 | P2RX3 (0.41) | THRBRORCP2RX3P2RX2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021078120-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES | NOVARTIS AG (CH) | 2021-04-29 | — | — | WO | disclosed |