SCHEMBL1832191

SCHEMBL1832191

CN(C)c1ccc(-c2ccc(C(OCc3ccccc3)c3ccc(-c4ccc(N(C)C)cc4)cc3)cc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.48
ALDH1A1 P00352 3/20 0.47
MAPT P10636 2/20 0.47
HPGD P15428 1/20 0.47
POLB P06746 2/20 0.44
NPSR1 Q6W5P4 1/20 0.44
SLC6A2 P23975 2/20 0.43
SLC6A4 P31645 2/20 0.43
SLC6A3 Q01959 2/20 0.43
SIGMAR1 Q99720 1/20 0.43
CNR2 P34972 1/20 0.43
RXFP1 Q9HBX9 1/20 0.43
LMNA P02545 2/20 0.42
CYP1A2 P05177 1/20 0.42
CHRM2 P08172 1/20 0.42
CHRM4 P08173 1/20 0.42
CHRM5 P08912 1/20 0.42
ADRA2A P08913 1/20 0.42
CYP2D6 P10635 1/20 0.42
CHRM1 P11229 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1446635 0.95 MAPK1 (0.51) MAPK1ALDH1A1MAPTHPGDPOLB
SCHEMBL8777555 0.82 MAPK1 (0.42) MAPK1ALDH1A1MAPTHPGDPOLB
SCHEMBL1832190 0.81 SLC6A2 (0.40) MAPK1SLC6A2SLC6A4SLC6A3SIGMAR1
SCHEMBL8777531 0.80 CYP2D6 (0.43) MAPK1ALDH1A1MAPTHPGDPOLB
SCHEMBL11265024 0.79 SLC6A4 (0.58) MAPK1ALDH1A1MAPTNPSR1SLC6A2
SCHEMBL10431978 0.77 SLC6A2 (0.50) MAPK1MAPTSLC6A2SLC6A4SLC6A3
SCHEMBL8777670 0.76 MAPK1 (0.38) MAPK1ALDH1A1MAPTHPGDPOLB
SCHEMBL8777532 0.76 ALDH1A1 (0.38) MAPK1ALDH1A1MAPTHPGDNPSR1
SCHEMBL8777548 0.76 MAPK1 (0.39) MAPK1ALDH1A1MAPTHPGDPOLB
SCHEMBL8777642 0.74 TDP1 (0.41) MAPK1ALDH1A1MAPTHPGDPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2452970-B1 Use of a crosslinking agent, crosslinked polymer, and uses thereof NIPPON SYNTHETIC CHEM IND (JP) 2015-01-21 EP disclosed
US-8664333-B2 Acetoacetic ester group-containing polyvinyl alcohol-based resin, resin composition, and uses thereof THE NIPPON SYNTHETIC CHEMICAL INDUSTRY CO., LTD. (JP) 2014-03-04 US disclosed
US-8426632-B2 Crosslinking agent, crosslinked polymer, and uses thereof THE NIPPON SYNTHETIC CHEMICAL INDUSTRY CO., LTD. (JP) 2013-04-23 US disclosed
EP-2452970-A1 Crosslinking agent, crosslinked polymer, and uses thereof The Nippon Synthetic Chemical Industry Co., Ltd. (JP) 2012-05-16 EP disclosed
EP-1923227-B1 A structure with a built-in recording medium, a laminate comprising the structure and method for recording in non-contact manner using the structure and the laminate LINTEC CORP (JP) 2011-05-11 EP disclosed
US-7939464-B2 Resin laminate material with a built-in recording medium with a means for rewriting visible information with a laser light in a non-contact manner; recording and erasing of information can be conducted by irradiation with a laser light from outside LINTEC CORPORATION (JP) 2011-05-10 US disclosed
US-20100209723-A1 CROSSLINKING AGENT, CROSSLINKED POLYMER, AND USES THEREOF THE NIPPON SYNTHETIC CHEMICAL INDUSTRY CO., LTD. (JP) 2010-08-19 US disclosed
EP-2189496-A1 CROSSLINKING AGENT, CROSSLINKED POLYMER AND THEIR USES The Nippon Synthetic Chemical Industry Co., Ltd. (JP) 2010-05-26 EP disclosed
EP-1988123-B1 RESIN COMPOSITION AND USE THEREOF NIPPON SYNTHETIC CHEM IND (JP) 2010-04-21 EP disclosed
EP-1930352-B1 ACETOACETIC-ESTER-GROUP CONTAINING POLYVINYL ALCOHOL RESIN, RESIN COMPOSITION AND USE THEREOF NIPPON SYNTHETIC CHEM IND (JP) 2010-02-10 EP disclosed
US-6232266-B1 COMPRISES TWO OR MORE KINDS OF COMPOUNDS, AND AT LEAST ONE OF WHICH IS FORMED A COLOR-FORMATION CONTROLLING LAYER OBTAINED BY POLYMERIZING A COMPOUND HAVING AN UNSATURATED CARBON BOND. MITSUBISHI PAPER MILLS LIMITED (JP) 2001-05-15 US disclosed
US-6001518-A REVERSIBLE HEAT-SENSITIVE RECORDING LAYER IS FORMED BY A REVERSIBLE HEAT-SENSITIVE RECORDING MATERIAL INCLUDING LEUCO DYE AND A COLOR DEVELOPING/REDUCING AGENT KYODO PRINTING CO., LTD. (JP) 1999-12-14 US disclosed
EP-0870624-A1 Reversible heat-sensitive recording material Kyodo Printing Co., Ltd. (JP) 1998-10-14 EP disclosed
EP-0648612-B1 Reversible heat-sensitive recording material MITSUBISHI PAPER MILLS LTD (JP) 1998-06-10 EP disclosed
US-5498772-A SUBSTRATE WITH HEAT SENSITIVE LAYER AND OPTICAL RECORDING LAYER MITSUBISHI PAPER MILLS LIMITED (JP) 1996-03-12 US disclosed
EP-0648612-A1 Reversible heat-sensitive recording material MITSUBISHI PAPER MILLS, LTD. (JP) 1995-04-19 EP disclosed
EP-0484874-B1 HEAT-SENSITIVE RECORDING MATERIAL MITSUBISHI PAPER MILLS, LTD. (JP) 1993-08-11 EP disclosed
US-5179068-A A support with a dye precursor, a developer, a binder and an aromatic ether compound MITSUBISHI PAPER MILLS LIMITED (JP) 1993-01-12 US disclosed
EP-0484874-A1 Heat-sensitive recording material MITSUBISHI PAPER MILLS, LTD. (JP) 1992-05-13 EP disclosed
US-5063197-A Aromatic compound MITSUBISHI PAPER MILLS LIMITED (JP) 1991-11-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100209723-A1 CROSSLINKING AGENT, CROSSLINKED POLYMER, AND USES THEREOF GRHPR, GLO1, AGXT MAPK1 2512/4885ALDH1A1 353/4885MAPT 3320/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.