Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29838626 | 0.85 | MAPT (0.44) | PKMALDH1A1TDP1KMT2AMAPT | |
| SCHEMBL28191633 | 0.85 | MAPT (0.44) | PKMALDH1A1TDP1KMT2AMAPT | |
| SCHEMBL25394055 | 0.81 | GRIN2D (0.40) | PKMALDH1A1TDP1KMT2AMAPT | |
| SCHEMBL14868671 | 0.81 | HSP90AA1 (0.41) | PKMALDH1A1TDP1KMT2AMAPT | |
| SCHEMBL31389931 | 0.81 | ALDH1A1 (0.38) | PKMALDH1A1TDP1KMT2AMAPT | |
| SCHEMBL3922708 | 0.77 | PKM (0.42) | PKMALDH1A1TDP1KMT2AMAPT | |
| SCHEMBL5216651 | 0.76 | ALDH1A1 (0.43) | PKMALDH1A1TDP1KMT2AMAPT | |
| SCHEMBL29892635 | 0.76 | ALDH1A1 (0.43) | PKMALDH1A1TDP1KMT2AMAPT | |
| SCHEMBL12102640 | 0.74 | ALDH1A1 (0.44) | PKMALDH1A1TDP1KMT2AMAPT | |
| SCHEMBL29735712 | 0.74 | ALDH1A1 (0.42) | PKMALDH1A1TDP1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105753779-B | 2- pyridyl amine compounds and preparation method and application | 湖南化工研究院有限公司 | 2018-06-26 | — | — | CN | claimed |
| CN-105753779-A | 2-pyridylamine compounds, preparing method thereof and applications of the compounds | 湖南化工研究院有限公司 | 2016-07-13 | — | — | CN | claimed |
| CN-108112251-B | NRF2 modulators | 葛兰素史克知识产权发展有限公司 | 2021-03-05 | — | — | CN | disclosed |
| CN-107820494-B | Nuclear receptor modulators | 艾伯维公司 | 2020-10-16 | — | — | CN | disclosed |
| CN-105753779-B | 2- pyridyl amine compounds and preparation method and application | 湖南化工研究院有限公司 | 2018-06-26 | — | — | CN | disclosed |
| CN-105916857-B | Pyrrolopyrrolone derivatives and its purposes as BET inhibitor | 诺华股份有限公司 | 2018-06-22 | — | — | CN | disclosed |
| CN-105209467-B | Imidazopyrrolidinone derivatives and their use in the treatment of disease | 诺华股份有限公司 | 2018-06-08 | — | — | CN | disclosed |
| CN-108112251-A | NRF2 conditioning agents | 葛兰素史克知识产权发展有限公司 | 2018-06-01 | — | — | CN | disclosed |
| EP-3307739-A1 | NRF2 REGULATORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2018-04-18 | — | — | EP | disclosed |
| CN-107849024-A | With as indoleamine 2, the benzimidazole and imidazopyridine imido of 3 dioxygenase inhibitor activities are for benzamide compound | 吉利德科学公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-107820494-A | Nuclear receptor modulators | 艾伯维公司 | 2018-03-20 | — | — | CN | disclosed |
| CN-105408335-B | Pyrazolo pyrrolidin derivatives and its purposes in disease is treated | 诺华股份有限公司 | 2017-11-17 | — | — | CN | disclosed |
| WO-2016202253-A1 | NRF2 REGULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2016-12-22 | — | — | WO | disclosed |
| CN-105916857-A | Pyrrolopyrrolone derivatives and their use as BET inhibitors | 诺华股份有限公司 | 2016-08-31 | — | — | CN | disclosed |
| CN-105753779-A | 2-pyridylamine compounds, preparing method thereof and applications of the compounds | 湖南化工研究院有限公司 | 2016-07-13 | — | — | CN | disclosed |
| CN-105209467-A | Imidazopyrrolidinone derivatives and their use in the treatment of disease | NOVARTIS AG | 2015-12-30 | — | — | CN | disclosed |