Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR2 | P30874 | 3/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.36 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.36 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18322893 | 0.90 | SSTR2 (0.41) | SSTR2HRH3ADRA1AKCNH2CHRM4 | |
| SCHEMBL18322921 | 0.86 | HRH3 (0.42) | SSTR2HRH3ADRA1AKCNH2MEN1 | |
| SCHEMBL18322980 | 0.84 | HRH3 (0.42) | HRH3ADRA1AKCNH2HTR2AHTR7 | |
| SCHEMBL18322841 | 0.84 | HRH3 (0.42) | HRH3RAB9ANPC1ADRA1AKCNH2 | |
| SCHEMBL18319018 | 0.82 | SSTR2 (0.43) | SSTR2HRH3RAB9ANPC1ALDH1A1 | |
| SCHEMBL18319044 | 0.77 | NAMPT (0.51) | SSTR2ALDH1A1KDM4E | |
| SCHEMBL18319042 | 0.77 | NAMPT (0.51) | SSTR2ALDH1A1KDM4E | |
| SCHEMBL18322938 | 0.76 | CHRNB1 (0.43) | HRH3ADRA1AKCNH2 | |
| SCHEMBL18318480 | 0.73 | PIK3CD (0.44) | SSTR2RAB9AALDH1A1SMN1; SMN2KCNH2 | |
| SCHEMBL18322895 | 0.72 | HRH3 (0.40) | HRH3ALDH1A1ADRA1AKCNH2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3310441-A1 | 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES | Cephalon, Inc. (US) | 2018-04-25 | — | — | EP | disclosed |
| WO-2016205633-A1 | 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES | CEPHALON, INC. (US) | 2016-12-22 | — | — | WO | disclosed |