Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.42 |
| ▸ | HTR2A | P28223 | 4/20 | 0.39 |
| ▸ | HTR7 | P34969 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.37 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | DRD4 | P21917 | 3/20 | 0.35 |
| ▸ | DRD3 | P35462 | 3/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18322921 | 0.86 | HRH3 (0.42) | HRH3HTR2AHTR7KCNH2ADRA1A | |
| SCHEMBL18322841 | 0.86 | HRH3 (0.42) | HRH3HTR2AHTR7KCNH2ADRA1A | |
| SCHEMBL18322930 | 0.84 | SSTR2 (0.43) | HRH3HTR2AHTR7KCNH2ADRA1A | |
| SCHEMBL18322893 | 0.84 | SSTR2 (0.41) | HRH3HTR2AHTR7KCNH2ADRA1A | |
| SCHEMBL18322895 | 0.80 | HRH3 (0.40) | HRH3HTR2AHTR7KCNH2ADRA1A | |
| SCHEMBL18318221 | 0.79 | MAPT (0.46) | — | |
| SCHEMBL18322938 | 0.79 | CHRNB1 (0.43) | HRH3KCNH2ADRA1ACARM1PRMT6 | |
| SCHEMBL18318308 | 0.79 | PIK3CD (0.44) | — | |
| SCHEMBL18318488 | 0.78 | NAMPT (0.46) | HRH3KCNH2ADRA1A | |
| SCHEMBL18322951 | 0.77 | PRKCZ (0.42) | HRH3HTR2AHTR7KCNH2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3310441-A1 | 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES | Cephalon, Inc. (US) | 2018-04-25 | — | — | EP | disclosed |
| WO-2016205633-A1 | 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES | CEPHALON, INC. (US) | 2016-12-22 | — | — | WO | disclosed |