Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 1/20 | 0.42 |
| ▸ | CCR3 | P51677 | 11/20 | 0.39 |
| ▸ | HRH1 | P35367 | 11/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18322881 | 0.89 | PRKCZ (0.42) | PRKCZROCK1ROCK2CCR2CHRNB1 | |
| SCHEMBL18322937 | 0.88 | PRKCZ (0.41) | PRKCZCHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL18322938 | 0.87 | CHRNB1 (0.43) | PRKCZCHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL19888915 | 0.85 | HRH1 (0.41) | PRKCZCCR3HRH1ROCK1ROCK2 | |
| SCHEMBL18322956 | 0.85 | PRMT5 (0.47) | PRKCZCCR3HRH1CHRNB1CHRNB2 | |
| SCHEMBL18318090 | 0.80 | PIK3CD (0.44) | PRKCZCCR3HRH1 | |
| SCHEMBL18318612 | 0.80 | PIK3CA (0.53) | PRKCZ | |
| SCHEMBL18322895 | 0.79 | HRH3 (0.40) | CCR3HRH1ROCK1ROCK2CCR2 | |
| SCHEMBL18318431 | 0.78 | PIK3CA (0.47) | PRKCZCCR3HRH1HRH3 | |
| SCHEMBL18322929 | 0.77 | CHRNB1 (0.42) | PRKCZROCK1ROCK2CCR2CHRNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3310441-A1 | 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES | Cephalon, Inc. (US) | 2018-04-25 | — | — | EP | disclosed |
| WO-2016205633-A1 | 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES | CEPHALON, INC. (US) | 2016-12-22 | — | — | WO | disclosed |