Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.42 |
| ▸ | ESR1 | P03372 | 3/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | FASN | P49327 | 3/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | FDPS | P14324 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18322904 | 0.94 | GSK3B (0.42) | GSK3BPDE3BPDE3APDE10ACHEK2 | |
| SCHEMBL18322946 | 0.79 | HTR7 (0.37) | GSK3BCHEK2HTR7HTR1AROCK1 | |
| SCHEMBL18322979 | 0.78 | GSK3B (0.42) | GSK3BFASNDRD2HTR7 | |
| SCHEMBL18318608 | 0.77 | PIK3CD (0.54) | GSK3BPDE3BPDE3APDE10AFASN | |
| SCHEMBL18318113 | 0.77 | PIK3CD (0.54) | GSK3BPDE3BPDE3APDE10AFASN | |
| SCHEMBL18318114 | 0.77 | PIK3CD (0.54) | GSK3BPDE3BPDE3APDE10AFASN | |
| SCHEMBL18322976 | 0.77 | ROCK1 (0.39) | HTR1AFDPSROCK1 | |
| SCHEMBL18322938 | 0.76 | CHRNB1 (0.43) | CHEK2FASN | |
| Hydrochloric Acid SCHEMBL18318506 | 0.76 | PIK3CD (0.53) | GSK3BPDE3BPDE3APDE10AFASN | |
| Hydrochloric Acid SCHEMBL18318626 | 0.76 | PIK3CD (0.53) | GSK3BPDE3BPDE3APDE10AFASN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3310441-A1 | 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES | Cephalon, Inc. (US) | 2018-04-25 | — | — | EP | disclosed |
| WO-2016205633-A1 | 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES | CEPHALON, INC. (US) | 2016-12-22 | — | — | WO | disclosed |