Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202817 | 0.82 | GAA (0.66) | RXFP1GAANPSR1CYP1A2SMN1; SMN2 | |
| SCHEMBL6538738 | 0.77 | POLB (0.51) | TRPM8SMN1; SMN2POLB | |
| SCHEMBL5748928 | 0.74 | PTGS2 (0.55) | CYP1A2CYP2C19SMN1; SMN2POLBMAPT | |
| SCHEMBL11817150 | 0.74 | PPARA (0.63) | GAANPSR1MAPT | |
| SCHEMBL14518119 | 0.72 | MAPT (0.61) | SMN1; SMN2POLBMAPT | |
| SCHEMBL12869146 | 0.72 | PPARA (0.69) | GAANPSR1 | |
| SCHEMBL6538743 | 0.72 | NPC1 (0.52) | TRPM8SMN1; SMN2POLBMAPT | |
| SCHEMBL4477658 | 0.72 | SMN1; SMN2 (0.63) | TRPM8GAAHTTSMN1; SMN2 | |
| SCHEMBL15922116 | 0.71 | PPARA (0.71) | GAANPSR1CYP3A4SMN1; SMN2 | |
| SCHEMBL28405319 | 0.71 | PPARA (0.71) | GAANPSR1CYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9522149-B2 | Pyrazine derivatives as ENaC blockers | NOVARTIS AG (CH) | 2016-12-20 | — | — | US | disclosed |
| US-9522149-B2 | Pyrazine derivatives as ENaC blockers | NOVARTIS AG (CH) | 2016-12-20 | — | — | US | disclosed |