Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
| ▸ | PDE8A | O60658 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18323582 | 0.87 | POLB (0.50) | POLBBRD4KMT2APDE8APDE4A | |
| SCHEMBL18323624 | 0.84 | POLB (0.36) | POLBLMNAHTTTSHRBRD4 | |
| SCHEMBL18323639 | 0.80 | BRD4 (0.40) | POLBLMNAHTTBRD4KMT2A | |
| SCHEMBL18323625 | 0.80 | POLB (0.34) | POLBTSHRBRD4 | |
| SCHEMBL18323673 | 0.79 | TSHR (0.43) | POLBLMNAHTTTSHRKMT2A | |
| SCHEMBL18323678 | 0.78 | CYP2C9 (0.35) | POLBTSHR | |
| SCHEMBL18323691 | 0.78 | MET (0.34) | POLBLMNAHTTTSHRPDE8A | |
| SCHEMBL15907122 | 0.77 | MEN1 (0.49) | LMNAHTTKMT2APARP1 | |
| SCHEMBL10377617 | 0.75 | POLB (0.38) | POLB | |
| SCHEMBL18323670 | 0.73 | MKNK1 (0.34) | POLBLMNATSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9522910-B2 | Protein kinase inhibitors (variants), use thereof in treating oncological diseases and a pharmaceutical composition based thereon | Obshchestvo s ogranichennoy otvetstvennostyou “Fusion Pharma” (RU) | 2016-12-20 | — | — | US | disclosed |