Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.37 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.37 |
| ▸ | BPTF | Q12830 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18323621 | 0.85 | TSHR (0.44) | TSHRLMNAHTTPARP10NCOA1 | |
| SCHEMBL15907090 | 0.82 | TSHR (0.41) | TSHRLMNAHTTPARP10NCOA1 | |
| SCHEMBL18323624 | 0.80 | POLB (0.36) | TSHRLMNAHTTKMT2APOLB | |
| SCHEMBL18323623 | 0.79 | POLB (0.49) | TSHRLMNAHTTKMT2APOLB | |
| SCHEMBL18323691 | 0.77 | MET (0.34) | TSHRLMNAHTTNCOA1NCOA3 | |
| SCHEMBL18323665 | 0.77 | KDM4E (0.40) | HTTKMT2APOLBKDM4EMAPT | |
| SCHEMBL18323625 | 0.77 | POLB (0.34) | TSHRPOLB | |
| SCHEMBL18323678 | 0.75 | CYP2C9 (0.35) | TSHRPOLB | |
| SCHEMBL18323607 | 0.74 | KDM4E (0.41) | LMNAHTTPOLBKDM4EALDH1A1 | |
| SCHEMBL18323633 | 0.72 | BRD4 (0.38) | TSHRLMNAHTTPARP10BPTF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9522910-B2 | Protein kinase inhibitors (variants), use thereof in treating oncological diseases and a pharmaceutical composition based thereon | Obshchestvo s ogranichennoy otvetstvennostyou “Fusion Pharma” (RU) | 2016-12-20 | — | — | US | disclosed |