Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | USP7 | Q93009 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18323598 | 0.79 | KDM4E (0.47) | MKNK1MKNK2LMNAEGLN2KMT2A | |
| SCHEMBL15907134 | 0.75 | AURKA (0.35) | MKNK1MKNK2LMNAEGLN2KMT2A | |
| SCHEMBL11629603 | 0.74 | MAPK1 (0.38) | MKNK1MKNK2FYNPIK3CAATR | |
| SCHEMBL17234928 | 0.74 | DNMT1 (0.44) | KMT2APOLBMET | |
| SCHEMBL18323624 | 0.74 | POLB (0.36) | LMNAKMT2ATSHRPOLBMET | |
| SCHEMBL18323623 | 0.73 | POLB (0.49) | LMNAKMT2ATSHRPOLB | |
| SCHEMBL11627214 | 0.72 | MET (0.54) | KMT2AFYNPOLBPIK3CAATR | |
| SCHEMBL18323625 | 0.71 | POLB (0.34) | TSHRPOLB | |
| SCHEMBL18323673 | 0.70 | TSHR (0.43) | LMNAKMT2ATSHRPOLBMET | |
| SCHEMBL18323691 | 0.69 | MET (0.34) | LMNATSHRPOLBMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9522910-B2 | Protein kinase inhibitors (variants), use thereof in treating oncological diseases and a pharmaceutical composition based thereon | Obshchestvo s ogranichennoy otvetstvennostyou “Fusion Pharma” (RU) | 2016-12-20 | — | — | US | disclosed |