Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18468618 | 0.86 | CYP3A4 (0.37) | HDAC4HDAC2HDAC8CYP3A4CYP2C9 | |
| SCHEMBL26007787 | 0.85 | HDAC4 (0.44) | HDAC4HDAC2HDAC8USP2ALDH1A1 | |
| SCHEMBL18324218 | 0.74 | GRIA2 (0.36) | CYP3A4CYP2C9HSD11B1CYP2C19ALDH1A1 | |
| SCHEMBL21484164 | 0.74 | ACACB (0.36) | HDAC4HDAC2HDAC8PTGS2ACACB | |
| SCHEMBL13975261 | 0.74 | DRD2 (0.39) | CYP3A4CYP2C9HSD11B1CYP2C19ALDH1A1 | |
| SCHEMBL25884992 | 0.74 | HDAC4 (0.45) | HDAC4HDAC2HDAC8CYP3A4CYP2C9 | |
| SCHEMBL14501877 | 0.72 | ACACB (0.40) | HDAC4HDAC2HDAC8CYP3A4HSD11B1 | |
| SCHEMBL18650813 | 0.71 | PTPN5 (0.45) | HDAC4HDAC2HDAC8CYP3A4CYP2C9 | |
| SCHEMBL22559358 | 0.70 | MEN1 (0.36) | CYP3A4CYP2C9HSD11B1CYP2C19MEN1 | |
| SCHEMBL591171 | 0.70 | MEN1 (0.36) | CYP3A4CYP2C9HSD11B1CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10323022-B2 | Pyrrolidinyl urea, pyrrolidinyl thiourea and pyrrolidinyl guanidine compounds as TrkA kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2019-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10323022-B2 | Pyrrolidinyl urea, pyrrolidinyl thiourea and pyrrolidinyl guanidine compounds as TrkA kinase inhibitors | RET, TK1, DSTYK | HDAC4 3655/4885HDAC2 3910/4885HDAC8 3337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.