Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.65 |
| ▸ | DRD2 | P14416 | 4/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.57 |
| ▸ | HTR2A | P28223 | 3/20 | 0.52 |
| ▸ | HTR7 | P34969 | 3/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
| ▸ | CCR2 | P41597 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.51 |
| ▸ | SPR | P35270 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21758792 | 0.92 | HSD11B1 (0.60) | HSD11B1DRD2SLC6A4ADRA1DHTR2A | |
| SCHEMBL18324848 | 0.89 | HSD11B1 (0.57) | HSD11B1DRD2SLC6A4ADRA1DHTR2A | |
| SCHEMBL18324838 | 0.88 | HSD11B1 (0.55) | HSD11B1DRD2SLC6A4ADRA1DHTR2A | |
| SCHEMBL6184605 | 0.88 | DRD2 (0.61) | HSD11B1DRD2SLC6A4ADRA1DHTR2A | |
| SCHEMBL16802074 | 0.86 | KDM4E (0.69) | HSD11B1DRD2SLC6A4ADRA1DHTR2A | |
| SCHEMBL18324842 | 0.86 | DRD2 (0.66) | HSD11B1DRD2SLC6A4ADRA1DHTR2A | |
| SCHEMBL18324845 | 0.84 | DRD2 (0.61) | HSD11B1DRD2SLC6A4ADRA1DHTR2A | |
| SCHEMBL18324833 | 0.84 | DRD2 (0.58) | HSD11B1DRD2SLC6A4ADRA1DHTR2A | |
| SCHEMBL18701706 | 0.84 | DRD2 (0.61) | HSD11B1DRD2SLC6A4ADRA1DHTR2A | |
| SCHEMBL18324841 | 0.83 | DRD2 (0.60) | HSD11B1DRD2SLC6A4ADRA1DHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3082802-B1 | TRYPTOPHAN-2,3-DIOXYGENASE (TDO) AND/OR INDOLAMINE-2,3-DIOXYGENASE (IDO) INHIBITORS AND THEIR USE | IOMET PHARMA LTD (GB) | 2020-02-26 | — | — | EP | disclosed |
| US-9931347-B2 | Pharmaceutical compound | IOMET PHARMA LTD. (US) | 2018-04-03 | — | — | US | disclosed |
| US-9931347-B2 | Pharmaceutical compound | IOMET PHARMA LTD. (US) | 2018-04-03 | — | — | US | disclosed |
| US-20160367564-A1 | Pharmaceutical Compound | IOMET PHARMA LTD. (GB) | 2016-12-22 | — | — | US | disclosed |
| US-20160367564-A1 | Pharmaceutical Compound | IOMET PHARMA LTD. (GB) | 2016-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160367564-A1 | Pharmaceutical Compound | TDO2, IDO1, IDO2 | HSD11B1 783/4885DRD2 447/4885SLC6A4 73/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.