Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 3/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.46 |
| ▸ | MYC | P01106 | 1/20 | 0.40 |
| ▸ | CAPN1 | P07384 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.34 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17725519 | 0.85 | MYC (0.57) | HCRTR1HCRTR2MYCCAPN1ALDH1A1 | |
| SCHEMBL18329236 | 0.85 | HCRTR1 (0.48) | HCRTR1HCRTR2MYCCAPN1ALDH1A1 | |
| SCHEMBL19652347 | 0.76 | PDE10A (0.39) | HCRTR1HCRTR2ALDH1A1PDE10AMAPK1 | |
| SCHEMBL16547469 | 0.75 | PDE10A (0.42) | HCRTR1HCRTR2ALDH1A1PDE10AMAPK1 | |
| SCHEMBL12528560 | 0.72 | HSD11B1 (0.42) | HCRTR1HCRTR2ALDH1A1PDE10AMAPK1 | |
| SCHEMBL19659251 | 0.71 | PDE10A (0.37) | HCRTR1HCRTR2CAPN1ALDH1A1PDE10A | |
| SCHEMBL14149724 | 0.71 | L3MBTL1 (0.40) | HCRTR1HCRTR2ALDH1A1L3MBTL1NPC1 | |
| SCHEMBL2625484 | 0.71 | P2RX7 (0.56) | MYCALDH1A1L3MBTL1NPC1MAPT | |
| SCHEMBL16543488 | 0.70 | TRPV1 (0.35) | ALDH1A1L3MBTL1NPC1MAPTRAB9A | |
| SCHEMBL13543163 | 0.68 | KDM4E (0.42) | MYCALDH1A1L3MBTL1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9586934-B2 | 2-pyridyloxy-4-methyl orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2017-03-07 | — | — | US | disclosed |
| US-9586934-B2 | 2-pyridyloxy-4-methyl orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2017-03-07 | — | — | US | disclosed |
| US-20160368898-A1 | 2-PYRIDYLOXY-4-METHYL OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2016-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160368898-A1 | 2-PYRIDYLOXY-4-METHYL OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, NPY2R | HCRTR1 2/4885HCRTR2 1/4885MYC 4839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.