Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.67 |
| ▸ | RAB9A | P51151 | 6/20 | 0.67 |
| ▸ | LMNA | P02545 | 4/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | WDR5 | P61964 | 8/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15933686 | 0.91 | NPC1 (0.61) | NPC1RAB9ALMNAHTTWDR5 | |
| SCHEMBL18329393 | 0.86 | WDR5 (0.48) | NPC1RAB9ALMNAHTTWDR5 | |
| SCHEMBL18329398 | 0.85 | WDR5 (0.65) | NPC1RAB9ALMNAHTTWDR5 | |
| SCHEMBL18329424 | 0.82 | WDR5 (0.45) | NPC1RAB9ALMNAHTTWDR5 | |
| SCHEMBL10747985 | 0.78 | PDCD1 (0.53) | NPC1RAB9ALMNAHTTWDR5 | |
| SCHEMBL24517436 | 0.78 | NPC1 (0.88) | NPC1RAB9ALMNAHTTWDR5 | |
| SCHEMBL15933525 | 0.77 | PDCD1 (0.52) | NPC1RAB9ALMNAHTTWDR5 | |
| SCHEMBL15933440 | 0.77 | PDCD1 (0.59) | NPC1RAB9ALMNAHTTWDR5 | |
| SCHEMBL10747141 | 0.77 | PDCD1 (0.52) | NPC1RAB9ALMNAHTTWDR5 | |
| SCHEMBL12781800 | 0.77 | PDCD1 (0.52) | NPC1RAB9ALMNAHTTWDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10426784-B2 | Imidazodiazepine compound | ASTELLAS PHARMA INC. (JP) | 2019-10-01 | — | — | US | disclosed |
| EP-3312181-B1 | IMIDAZODIAZEPINE COMPOUND | ASTELLAS PHARMA INC (JP) | 2019-08-07 | — | — | EP | disclosed |
| US-20180185383-A1 | IMIDAZODIAZEPINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2018-07-05 | — | — | US | disclosed |
| US-20180185383-A1 | IMIDAZODIAZEPINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2018-07-05 | — | — | US | disclosed |
| EP-3312181-A1 | IMIDAZODIAZEPINE COMPOUND | Astellas Pharma Inc. (JP) | 2018-04-25 | — | — | EP | disclosed |
| WO-2016204268-A1 | IMIDAZODIAZEPINE COMPOUND | アステラス製薬株式会社 | 2016-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180185383-A1 | IMIDAZODIAZEPINE COMPOUND | HTR1D, DRD2, DRD1 | NPC1 2212/4885RAB9A 1308/4885LMNA 4214/4885 |
| US-10426784-B2 | Imidazodiazepine compound | GRIN2D, HTR1D, DRD2 | NPC1 1253/4885RAB9A 870/4885LMNA 4219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.