Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | DAO | P14920 | 1/20 | 0.61 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.61 |
| ▸ | CES1 | P23141 | 4/20 | 0.52 |
| ▸ | CES2 | O00748 | 3/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL28778321 | 0.91 | TSHR (0.57) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL1834003 | 0.87 | TSHR (0.61) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL5607281 | 0.86 | TSHR (0.74) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL7865148 | 0.86 | TSHR (0.74) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL1913806 | 0.86 | TSHR (0.74) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL974018 | 0.84 | TSHR (0.64) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL28648667 | 0.84 | TSHR (0.70) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL5082990 | 0.84 | TSHR (0.70) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL28327607 | 0.84 | TSHR (0.78) | TSHRDAONAPRTCES1CES2 | |
| Paraben SCHEMBL3687962 | 0.83 | CA2 (0.64) | TSHRCES2SRD5A2TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185330-A1 | Liquids | THE UNIVERSITY OF YORK (GB) | 2007-08-09 | — | — | US | claimed |
| EP-0086994-B1 | KARL FISCHER REAGENT AND METHOD FOR THE DETERMINATION OF WATER USING THIS REAGENT | MERCK PATENT GmbH (DE) | 1987-01-07 | — | — | EP | claimed |
| US-4550083-A | Karl-Fischer reagent and procedure for the determination of water using it | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1985-10-29 | — | — | US | claimed |
| US-11885782-B2 | Method of determining an amount of water in a sample using a sulfonic acid | HONEYWELL INTERNATIONAL INC. (US) | 2024-01-30 | — | — | US | disclosed |
| EP-4237843-A1 | METHOD OF DETERMINING AN AMOUNT OF WATER IN A SAMPLE USING A SULFONIC ACID | HONEYWELL INTERNATIONAL INC. (US) | 2023-09-06 | — | — | EP | disclosed |
| US-11714072-B2 | Reagent compositions and method for Karl Fischer titration | HONEYWELL INTERNATIONAL INC. (US) | 2023-08-01 | — | — | US | disclosed |
| US-20220137015-A1 | METHOD OF DETERMINING AN AMOUNT OF WATER IN A SAMPLE USING A SULFONIC ACID | HONEYWELL INTERNATIONAL INC. (US) | 2022-05-05 | — | — | US | disclosed |
| WO-2022094574-A1 | METHOD OF DETERMINING AN AMOUNT OF WATER IN A SAMPLE USING A SULFONIC ACID | HONEYWELL INTERNATIONAL INC. (US) | 2022-05-05 | — | — | WO | disclosed |
| EP-3948263-A1 | REAGENT COMPOSITIONS AND METHOD FOR KARL FISCHER TITRATION | Honeywell International Inc. (US) | 2022-02-09 | — | — | EP | disclosed |
| CN-113574379-A | Reagent composition and method for karl fischer titration | 霍尼韦尔国际公司 | 2021-10-29 | — | — | CN | disclosed |
| EP-3827257-A1 | METHOD OF DETERMINING AN AMOUNT OF WATER IN A SAMPLE USING A DERIVATIVE OF IMIDAZOLE AND A HYDROGEN HALIDE DONOR | Honeywell International Inc. (US) | 2021-06-02 | — | — | EP | disclosed |
| US-7247485-B1 | Karl Fischer reagent | TEKNIKBROSTIFTELSEN (SE) | 2007-07-24 | — | — | US | disclosed |
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |
| EP-1188052-A1 | KARL FISCHER REAGENT | Cedergren, Anders (SE) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000072003-A1 | KARL FISCHER REAGENT | CEDERGREN ANDERS (SE) | 2000-11-30 | — | — | WO | disclosed |
| US-5401662-A | Adduct of amine and sulfur dioxide, iodine | RIEDEL-DE HAEN AKTIENGESELLSCHAFT (DE) | 1995-03-28 | — | — | US | disclosed |
| US-5139955-A | Reactive base, sulfur dioxide, iodide, conducting salt dissolved in alcoholic solvent; membrane-free cell | RIEDEL-DE HAEN AG (DE) | 1992-08-18 | — | — | US | disclosed |
| US-4619900-A | Solvent for the determination of water by the Karl Fischer method | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-10-28 | — | — | US | disclosed |
| US-4550083-A | Karl-Fischer reagent and procedure for the determination of water using it | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1985-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11714072-B2 | Reagent compositions and method for Karl Fischer titration | JAK1, ADH1A, SALL4 | TSHR 354/4885DAO 1039/4885NAPRT 3779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.