Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.32 |
| ▸ | MT-CO2 | P00403 | 2/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.32 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | NQO2 | P16083 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.32 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18334469 | 0.78 | GAA (0.33) | GAAALDH1A1MTNR1AMTNR1BHCRTR2 | |
| SCHEMBL18334565 | 0.78 | GAA (0.33) | GAAALDH1A1MTNR1AMTNR1BHCRTR2 | |
| SCHEMBL18334499 | 0.78 | GAA (0.33) | GAAALDH1A1MTNR1AMTNR1BHCRTR2 | |
| SCHEMBL18334460 | 0.77 | MTNR1A (0.46) | GAAMTNR1AMTNR1BNQO2OPRD1 | |
| SCHEMBL18334543 | 0.76 | GAA (0.40) | GAAALDH1A1RAB9APOLBMTNR1A | |
| SCHEMBL18334436 | 0.74 | KDM4E (0.34) | GAAALDH1A1HCRTR2OPRD1KMT2A | |
| SCHEMBL18334479 | 0.73 | GAA (0.39) | GAAPOLBMTNR1AMTNR1BMT-CO2 | |
| SCHEMBL18334495 | 0.68 | GAA (0.33) | GAAALDH1A1POLBMTNR1AMTNR1B | |
| SCHEMBL18768145 | 0.68 | NAPRT (0.43) | GAAALDH1A1RAB9APOLBKMT2A | |
| SCHEMBL18334458 | 0.67 | GAA (0.57) | GAAALDH1A1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170107207-A1 | AMINOPYRAZOLONE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2017-04-20 | — | — | US | disclosed |
| EP-3109239-A1 | AMINOPYRAZOLONE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2016-12-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170107207-A1 | AMINOPYRAZOLONE DERIVATIVE | ATAD5, ATP1A1, TIPRL | GAA 2530/4885ALDH1A1 2821/4885GPR119 796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.