Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ELANE | P08246 | 8/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CCKBR | P32239 | 3/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18334463 | 0.83 | ESR1 (0.34) | ESR1KCNH2GAALMNAELANE | |
| SCHEMBL18334461 | 0.80 | MTNR1A (0.40) | GAALMNAALDH1A1PTGS1 | |
| SCHEMBL18334516 | 0.77 | LMNA (0.34) | LMNASMN1; SMN2ALDH1A1ABCB11PTGS1 | |
| SCHEMBL18334565 | 0.77 | GAA (0.33) | GAALMNAELANESMN1; SMN2ALDH1A1 | |
| SCHEMBL18334499 | 0.77 | GAA (0.33) | GAALMNAELANESMN1; SMN2ALDH1A1 | |
| SCHEMBL18334543 | 0.77 | GAA (0.40) | ESR1KCNH2GAALMNAELANE | |
| SCHEMBL18334469 | 0.77 | GAA (0.33) | GAALMNAELANESMN1; SMN2ALDH1A1 | |
| SCHEMBL18334510 | 0.74 | GAA (0.32) | GAAELANESMN1; SMN2ALDH1A1 | |
| SCHEMBL18334437 | 0.72 | LMNA (0.38) | GAALMNASMN1; SMN2ALDH1A1ABCB11 | |
| SCHEMBL18334557 | 0.72 | TSHR (0.39) | KCNH2GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170107207-A1 | AMINOPYRAZOLONE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2017-04-20 | — | — | US | disclosed |
| EP-3109239-A1 | AMINOPYRAZOLONE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2016-12-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170107207-A1 | AMINOPYRAZOLONE DERIVATIVE | ATAD5, ATP1A1, TIPRL | ESR1 3521/4885KCNH2 1048/4885GAA 2530/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.