Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.61 |
| ▸ | MIF | P14174 | 2/20 | 0.55 |
| ▸ | IDO1 | P14902 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | HTR2B | P41595 | 2/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | ACP3 | P15309 | 1/20 | 0.47 |
| ▸ | DAO | P14920 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9212090 | 0.90 | TAAR1 (0.57) | MEN1KMT2ATAAR1MIFIDO1 | |
| SCHEMBL30645106 | 0.90 | TAAR1 (0.57) | MEN1KMT2ATAAR1MIFIDO1 | |
| SCHEMBL10681526 | 0.83 | MEN1 (0.58) | MEN1KMT2ATAAR1MIFACP3 | |
| SCHEMBL5541700 | 0.82 | TAAR1 (0.61) | MEN1KMT2ATAAR1MIFIDO1 | |
| SCHEMBL38024 | 0.81 | TAAR1 (0.55) | MEN1KMT2ATAAR1MIFIDO1 | |
| SCHEMBL30096354 | 0.81 | TAAR1 (0.55) | MEN1KMT2ATAAR1MIFIDO1 | |
| SCHEMBL9106607 | 0.79 | LTA4H (0.47) | MEN1KMT2AALDH1A1MAOB | |
| SCHEMBL11825679 | 0.78 | TAAR1 (0.56) | MEN1KMT2ATAAR1MIFIDO1 | |
| SCHEMBL14549528 | 0.77 | TAAR1 (0.75) | TAAR1MIFIDO1HTR2AHTR2B | |
| SCHEMBL4716530 | 0.77 | TAAR1 (0.55) | MEN1KMT2ATAAR1MIFIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406211-B1 | A NEW METHOD FOR THE PREPARATION OF CINACALCET AND NEW INTERMEDIATES THEREOF | MEGAFINE PHARMA P LTD (IN) | 2018-06-27 | — | — | EP | disclosed |
| US-20150152040-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | AMNEAL PHARMACEUTICALS LLC (US) | 2015-06-04 | — | — | US | disclosed |
| US-20150152040-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | AMNEAL PHARMACEUTICALS LLC (US) | 2015-06-04 | — | — | US | disclosed |
| US-8969623-B2 | Method for the preparation of cinacalcet and intermediates and impurities thereof | Amneal Pharmaceuticals, LLC (US) | 2015-03-03 | — | — | US | disclosed |
| US-8969623-B2 | Method for the preparation of cinacalcet and intermediates and impurities thereof | Amneal Pharmaceuticals, LLC (US) | 2015-03-03 | — | — | US | disclosed |
| US-20140081048-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | MEGAFINE PHARMA (P) LTD. (IN) | 2014-03-20 | — | — | US | disclosed |
| US-20140081048-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | MEGAFINE PHARMA (P) LTD. (IN) | 2014-03-20 | — | — | US | disclosed |
| US-8575395-B2 | Method for the preparation of cinacalcet and intermediates and impurities thereof | Amneal Pharmaceuticals, LLC (US) | 2013-11-05 | — | — | US | disclosed |
| US-8575395-B2 | Method for the preparation of cinacalcet and intermediates and impurities thereof | Amneal Pharmaceuticals, LLC (US) | 2013-11-05 | — | — | US | disclosed |
| US-8455700-B2 | Method for producing phenylalkane-1-ols | BASF SE (DE) | 2013-06-04 | — | — | US | disclosed |
| WO-2007127449-A1 | PROCESS FOR THE PREPARATION OF CINACALCET BASE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2007-11-08 | — | — | WO | disclosed |
| US-20070259964-A1 | Process for the preparation of cinacalcet base | TEVA PHARMACEUTICALS USA, INC. | 2007-11-08 | — | — | US | disclosed |
| US-20070259964-A1 | Process for the preparation of cinacalcet base | TEVA PHARMACEUTICALS USA, INC. | 2007-11-08 | — | — | US | disclosed |
| US-20070260091-A1 | Process for the preparation of cinacalcet base | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2007-11-08 | — | — | US | disclosed |
| US-7250533-B2 | Process for preparing Cinacalcet hydrochloride | TEVA PHARMACEUTICAL INDUSTRIES LTD (IL) | 2007-07-31 | — | — | US | disclosed |
| US-7250533-B2 | Process for preparing Cinacalcet hydrochloride | TEVA PHARMACEUTICAL INDUSTRIES LTD (IL) | 2007-07-31 | — | — | US | disclosed |
| US-20070043243-A1 | Process for preparing Cinacalcet hydrochloride | TEVA PHARMACEUTICALS USA, INC. | 2007-02-22 | — | — | US | disclosed |
| US-20070043243-A1 | Process for preparing Cinacalcet hydrochloride | TEVA PHARMACEUTICALS USA, INC. | 2007-02-22 | — | — | US | disclosed |
| WO-2006125026-A2 | PROCESS FOR PREPARING CINACALCET HYDROCHLORIDE | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2006-11-23 | — | — | WO | disclosed |
| EP-0316733-A1 | 2-Amino pyrazolin-5-one | BAYER AG (DE) | 1989-05-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259964-A1 | Process for the preparation of cinacalcet base | KRAS, CA9, CA4 | MEN1 30/4885KMT2A 553/4885TAAR1 4215/4885 |
| US-20140081048-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | CMA1, SI, ALDH1A1 | MEN1 587/4885KMT2A 1217/4885TAAR1 1331/4885 |
| US-20070260091-A1 | Process for the preparation of cinacalcet base | KRAS, CA9, SI | MEN1 30/4885KMT2A 625/4885TAAR1 4124/4885 |
| US-20070043243-A1 | Process for preparing Cinacalcet hydrochloride | SI, PRCP, CA9 | MEN1 116/4885KMT2A 2904/4885TAAR1 4836/4885 |
| US-20150152040-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | CMA1, SI, ALDH1A1 | MEN1 587/4885KMT2A 1217/4885TAAR1 1331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.