Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12615133 | 0.80 | SMN1; SMN2 (0.47) | ALDH1A1SMN1; SMN2EPHB4POLBP2RX7 | |
| SCHEMBL28965333 | 0.80 | EPHB4 (0.60) | ALDH1A1SMN1; SMN2EPHB4POLBHPGD | |
| SCHEMBL28965330 | 0.80 | EPHB4 (0.65) | ALDH1A1SMN1; SMN2EPHB4P2RX7HPGD | |
| SCHEMBL16928098 | 0.77 | P2RX7 (0.49) | ALDH1A1SMN1; SMN2EPHB4POLBP2RX7 | |
| SCHEMBL6100736 | 0.76 | EPHB4 (0.57) | ALDH1A1SMN1; SMN2EPHB4POLBP2RX7 | |
| SCHEMBL28383426 | 0.76 | TTK (0.51) | SMN1; SMN2EPHB4POLBP2RX7HPGD | |
| SCHEMBL28437345 | 0.76 | JAK2 (0.54) | ALDH1A1SMN1; SMN2EPHB4POLBHPGD | |
| SCHEMBL2713240 | 0.76 | SMN1; SMN2 (0.59) | ALDH1A1SMN1; SMN2POLBHPGDCYP1A2 | |
| SCHEMBL11666677 | 0.75 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2POLBHPGDCYP1A2 | |
| SCHEMBL6228918 | 0.75 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2POLBHPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106316963-B | Polymorphs of a morpholino phenylaminopyrimidine compound or salt thereof | 苏州泽璟生物制药股份有限公司 | 2021-06-08 | — | — | CN | disclosed |
| CN-106316963-A | Polymorphic substances of morpholinophenylaminopyrimidine compound or salts thereof | 苏州泽璟生物制药有限公司 | 2017-01-11 | — | — | CN | disclosed |
| CN-106316963-A | Polymorphic substances of morpholinophenylaminopyrimidine compound or salts thereof | 苏州泽璟生物制药有限公司 | 2017-01-11 | — | — | CN | disclosed |
| WO-2016206634-A1 | MORPHOLINO PHENYL AMINO PYRIMIDINE COMPOUND OR POLYMORPH OF SALT THEREOF | 苏州泽璟生物制药有限公司 | 2016-12-29 | — | — | WO | disclosed |