Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 2/20 | 0.57 |
| ▸ | AURKA | O14965 | 2/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28965330 | 0.92 | EPHB4 (0.65) | EPHB4AURKAAURKBP2RX7SMN1; SMN2 | |
| SCHEMBL28445775 | 0.85 | AURKA (0.47) | EPHB4AURKAAURKBP2RX7ALDH1A1 | |
| SCHEMBL6982507 | 0.77 | PLK4 (0.67) | EPHB4AURKAAURKBSMN1; SMN2MAPK14 | |
| SCHEMBL28965333 | 0.77 | EPHB4 (0.60) | EPHB4AURKAAURKBSMN1; SMN2ALDH1A1 | |
| SCHEMBL3811820 | 0.77 | IGF1R (0.50) | EPHB4AURKAAURKBP2RX7SMN1; SMN2 | |
| SCHEMBL27613038 | 0.77 | AURKA (0.58) | EPHB4AURKAAURKBP2RX7SMN1; SMN2 | |
| SCHEMBL18335243 | 0.76 | ALDH1A1 (0.53) | EPHB4AURKAAURKBP2RX7SMN1; SMN2 | |
| SCHEMBL31620790 | 0.76 | NPSR1 (0.61) | EPHB4P2RX7SMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL23925278 | 0.75 | ALDH1A1 (0.51) | EPHB4P2RX7SMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL12614452 | 0.75 | P2RX7 (0.46) | P2RX7SMN1; SMN2ALDH1A1NPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7153964-B2 | Pyrimidine compounds | ASTRAZENECA AB (SE) | 2006-12-26 | — | — | US | disclosed |
| US-20030149064-A1 | Pyrimidine compounds | ASTRAZENECA AB (SE) | 2003-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149064-A1 | Pyrimidine compounds | CDK2, CCNI, CCNY | EPHB4 3797/4885AURKA 72/4885AURKB 97/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.