Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL6946373 | 1.00 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL19128 | 0.94 | CA4 (0.50) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL17685557 | 0.88 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL301926 | 0.88 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL7021729 | 0.88 | CA4 (0.60) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL15283203 | 0.88 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL950160 | 0.88 | — | — | |
| Bicarbonate SCHEMBL3359228 | 0.88 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL21875302 | 0.88 | — | — | |
| Bicarbonate SCHEMBL20597717 | 0.88 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117090705-A | Six-cylinder four-valve engine exhaust system and exhaust pipe | 广西玉柴机器股份有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-114672104-A | Environment-friendly methyl octabromoether flame-retardant master batch and preparation method and application thereof | 潍坊秀隆新材料有限公司 | 2022-06-28 | — | — | CN | disclosed |
| EP-3314634-B1 | METAL OXIDE BLOCKING DIELECTRIC LAYER FOR THREE-DIMENSIONAL MEMORY DEVICES | SANDISK TECHNOLOGIES LLC (US) | 2020-11-04 | — | — | EP | disclosed |
| EP-3314634-A1 | DIFFERENTIAL ETCH OF METAL OXIDE BLOCKING DIELECTRIC LAYER FOR THREE-DIMENSIONAL MEMORY DEVICES | SanDisk Technologies LLC (US) | 2018-05-02 | — | — | EP | disclosed |
| US-9842857-B2 | Differential etch of metal oxide blocking dielectric layer for three-dimensional memory devices | SANDISK TECHNOLOGIES LLC (US) | 2017-12-12 | — | — | US | disclosed |
| US-20170162597-A1 | DIFFERENTIAL ETCH OF METAL OXIDE BLOCKING DIELECTRIC LAYER FOR THREE-DIMENSIONAL MEMORY DEVICES | SanDisk Technologies, Inc. | 2017-06-08 | — | — | US | disclosed |
| US-9613977-B2 | Differential etch of metal oxide blocking dielectric layer for three-dimensional memory devices | SANDISK TECHNOLOGIES LLC (US) | 2017-04-04 | — | — | US | disclosed |
| US-20160379989-A1 | DIFFERENTIAL ETCH OF METAL OXIDE BLOCKING DIELECTRIC LAYER FOR THREE-DIMENSIONAL MEMORY DEVICES | SANDISK TECHNOLOGIES LLC | 2016-12-29 | — | — | US | disclosed |