Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | TYMS | P04818 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA3 | P07451 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL239430 | 0.85 | MEN1 (0.41) | ALDH1A1TDP1CYP3A4TYMSMEN1 | |
| SCHEMBL22288521 | 0.84 | MEN1 (0.46) | ALDH1A1TDP1CYP3A4MEN1KMT2A | |
| SCHEMBL25411924 | 0.84 | ALDH1A1 (0.37) | ALDH1A1TDP1CYP3A4TYMSMAPT | |
| SCHEMBL25637698 | 0.80 | ALDH1A1 (0.46) | ALDH1A1TDP1CYP3A4TYMSMEN1 | |
| SCHEMBL30118870 | 0.80 | ALDH1A1 (0.46) | ALDH1A1TDP1CYP3A4TYMSMEN1 | |
| SCHEMBL23035421 | 0.80 | ALDH1A1 (0.42) | ALDH1A1TDP1CYP3A4MEN1KMT2A | |
| SCHEMBL26908251 | 0.80 | VCP (0.40) | ALDH1A1TDP1CYP3A4TYMSMAPT | |
| SCHEMBL31281392 | 0.78 | TYMS (0.35) | ALDH1A1TDP1CYP3A4TYMSMAPT | |
| SCHEMBL18424404 | 0.77 | ALDH1A1 (0.40) | ALDH1A1TDP1CYP3A4TYMSMEN1 | |
| SCHEMBL6786414 | 0.77 | ALDH1A1 (0.48) | ALDH1A1TDP1CYP3A4TYMSMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160376297-A1 | Phosphorous Derivatives as Kinase Inhibitors | ARIAD PHARMA INC (US) | 2016-12-29 | — | — | US | disclosed |
| CN-102105150-B | Phosphorus derivatives as kinase inhibitors | ARIAD PHARMA INC | 2014-03-12 | — | — | CN | disclosed |
| CN-102105150-A | Phosphorus derivatives as kinase inhibitors | ARIAD PHARMA INC | 2011-06-22 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160376297-A1 | Phosphorous Derivatives as Kinase Inhibitors | MAP3K6, PIK3CA, MAP3K20 | ALDH1A1 4769/4885TDP1 2783/4885CYP3A4 3428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.