Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 13/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 13/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL239591 | 1.00 | ADORA2A (0.57) | ADORA2AADORA3LMNATP53ADORA1 | |
| SCHEMBL1833926 | 1.00 | ADORA2A (0.57) | ADORA2AADORA3LMNATP53ADORA1 | |
| SCHEMBL1412247 | 1.00 | ADORA2A (0.57) | ADORA2AADORA3LMNATP53ADORA1 | |
| SCHEMBL1412175 | 1.00 | ADORA2A (0.57) | ADORA2AADORA3LMNATP53ADORA1 | |
| SCHEMBL293365 | 1.00 | ADORA2A (0.57) | ADORA2AADORA3LMNATP53ADORA1 | |
| SCHEMBL1412177 | 1.00 | ADORA2A (0.57) | ADORA2AADORA3LMNATP53ADORA1 | |
| SCHEMBL1412193 | 0.91 | LMNA (0.47) | ADORA2AADORA3LMNATP53ADORA1 | |
| SCHEMBL1401959 | 0.90 | ADORA3 (0.68) | ADORA2AADORA3LMNATP53ADORA1 | |
| SCHEMBL10156160 | 0.89 | ADORA3 (0.55) | ADORA2AADORA3ADORA1 | |
| SCHEMBL12196646 | 0.89 | ADORA3 (0.55) | ADORA2AADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2322525-A1 | Purine derivatives for use as adenosin A2A receptor agonists | Novartis AG (CH) | 2011-05-18 | — | — | EP | disclosed |